Epidermal growth factor or serum stimulation of rat fibroblasts induces an elevation in mRNA levels for lactate dehydrogenase and other glycolytic enzymes

Lynn M. Matrisian, Guy Rautmann, Bruce E. Magun, Richard Breathnach

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Abstract

We have isolated cloned cDNAs corresponding to five mRNAs whose level is increased following stimulation of quiescent rat fibroblasts by either epidermal growth factor or serum. Partial sequencing followed by a computer search of data banks has shown that the cloned cDNA5 correspond to mRNAs encoding proteins with extensive homology to lactate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase, enol ase, tn ose phosphate isomerase, and actin. The complete nucleotide sequence of a rat fibroblast lactate dehydrogenase is presented.

Original languageEnglish (US)
Pages (from-to)711-726
Number of pages16
JournalNucleic acids research
Volume13
Issue number3
DOIs
StatePublished - Feb 11 1985

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ASJC Scopus subject areas

  • Genetics

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