TY - JOUR
T1 - Epidemiology and Course of Disease in Childhood Uveitis
AU - Smith, Janine A.
AU - Mackensen, Friederike
AU - Sen, H. Nida
AU - Leigh, Julie F.
AU - Watkins, Angela S.
AU - Pyatetsky, Dmitry
AU - Tessler, Howard H.
AU - Nussenblatt, Robert B.
AU - Rosenbaum, James T.
AU - Reed, George F.
AU - Vitale, Susan
AU - Smith, Justine R.
AU - Goldstein, Debra A.
N1 - Funding Information:
Supported in part by grants from Research to Prevent Blindness (Career Development Award to JRS, unrestricted grant to Casey Eye Institute and unrestricted grant to University of Illinois, DAG). Supported in part by the intramural research program of the National Eye Institute/National Institutes of Health/Department of Health and Human Services (JAS). The funding organizations participated in conducting the study, data collection, data management, and data analysis for the manuscript.
PY - 2009/8
Y1 - 2009/8
N2 - Purpose: To describe the disease characteristics and visual outcome of pediatric uveitis. Design: Retrospective, longitudinal observation. Participants: Five hundred twenty-seven pediatric uveitis patients from the National Eye Institute, University of Illinois, Chicago, and Oregon Health Sciences University. Methods: Retrospective chart review. Main Outcome Measures: Demographics, uveitis disease characteristics, complications, treatments, and visual outcomes were determined at baseline and at 1-, 3-, 5-, and 10-year time points. Results: The patient population was 54% female; 62.4% white, 12.5% black, 2.7% Asian, 2.1% multiracial, and 14.61% Hispanic. Median age at diagnosis was 9.4 years. The leading diagnoses were idiopathic uveitis (28.8%), juvenile idiopathic arthritis-associated uveitis (20.9%), and pars planitis (17.1%). Insidious onset (58%) and persistent duration (75.3%) were most common. Anterior uveitis was predominant (44.6%). Complications were frequent, and cystoid macular edema (odds ratio [OR] 2.94; P = 0.006) and hypotony (OR, 4.54; P = 0.026) had the most significant visual impact. Ocular surgery was performed in 18.9% of patients. The prevalence of legal blindness was 9.23% at baseline, 6.52% at 1 year, 3.17% at 3 years, 15.15% at 5 years, and 7.69% at 10 years. Posterior uveitis and panuveitis had more severe vision loss. Hispanic ethnicity was associated with a higher prevalence of infectious uveitis and vision loss at baseline. Conclusions: The rate and spectrum of vision threatening complications of pediatric uveitis are significant. Prospective studies using standard outcome measures and including diverse populations are needed to identify children most at risk. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.
AB - Purpose: To describe the disease characteristics and visual outcome of pediatric uveitis. Design: Retrospective, longitudinal observation. Participants: Five hundred twenty-seven pediatric uveitis patients from the National Eye Institute, University of Illinois, Chicago, and Oregon Health Sciences University. Methods: Retrospective chart review. Main Outcome Measures: Demographics, uveitis disease characteristics, complications, treatments, and visual outcomes were determined at baseline and at 1-, 3-, 5-, and 10-year time points. Results: The patient population was 54% female; 62.4% white, 12.5% black, 2.7% Asian, 2.1% multiracial, and 14.61% Hispanic. Median age at diagnosis was 9.4 years. The leading diagnoses were idiopathic uveitis (28.8%), juvenile idiopathic arthritis-associated uveitis (20.9%), and pars planitis (17.1%). Insidious onset (58%) and persistent duration (75.3%) were most common. Anterior uveitis was predominant (44.6%). Complications were frequent, and cystoid macular edema (odds ratio [OR] 2.94; P = 0.006) and hypotony (OR, 4.54; P = 0.026) had the most significant visual impact. Ocular surgery was performed in 18.9% of patients. The prevalence of legal blindness was 9.23% at baseline, 6.52% at 1 year, 3.17% at 3 years, 15.15% at 5 years, and 7.69% at 10 years. Posterior uveitis and panuveitis had more severe vision loss. Hispanic ethnicity was associated with a higher prevalence of infectious uveitis and vision loss at baseline. Conclusions: The rate and spectrum of vision threatening complications of pediatric uveitis are significant. Prospective studies using standard outcome measures and including diverse populations are needed to identify children most at risk. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article.
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U2 - 10.1016/j.ophtha.2009.05.002
DO - 10.1016/j.ophtha.2009.05.002
M3 - Article
C2 - 19651312
AN - SCOPUS:67949088381
SN - 0161-6420
VL - 116
SP - 1544-1551.e1
JO - Ophthalmology
JF - Ophthalmology
IS - 8
ER -