Epidemiologic contributions to understanding the etiology of uterine leiomyomata

Stephen M. Schwartz, Lynn Marshall, Donna D. Baird

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Uterine leiomyomata are hormonally dependent tumors that are a major source of gynecologic morbidity among women of reproductive age. Relatively few studies have attempted to identify specific risk factors for these neoplasms. In this review of epidemiologic contributions to the etiology of uterine leiomyomata, we begin by outlining methodologic issues in epidemiologic studies that arise from the fact that a large proportion of uterine leiomyomata does not come to medical attention. We then review the major findings from published epidemiologic studies, which to date have focused primarily on menstrual and childbearing history, exogenous hormone use, obesity, cigarette smoking, and other lifestyle and behavioral characteristics that may in part reflect aspects of a woman's hormonal milieu. None of the potential risk factors studied have demonstrated sufficiently consistent associations to guide decisions on the primary prevention of uterine leiomyomata. Clarifying the etiology and natural history of uterine leiomyomata will require studies designed to address methodologic issues and test hypotheses involving environmental and lifestyle influences on endocrine function, as well as on other possible etiologic mechanisms. Recent advances in molecular genetics present opportunities for epidemiologic studies of uterine leiomyomata to incorporate biomarkers of somatic changes found in these tumors and to examine inherited genetic factors related to possible causal physiologic mechanisms.

Original languageEnglish (US)
Pages (from-to)821-827
Number of pages7
JournalEnvironmental Health Perspectives
Volume108
Issue numberSUPPL. 5
StatePublished - 2000

Fingerprint

etiology
Leiomyoma
risk factor
lifestyle
tumor
Tumors
childbearing
obesity
Biomarkers
morbidity
history
smoking
Tobacco Products
hormone
biomarker
Epidemiologic Studies
Hormones
Life Style
Neoplasms
Primary Prevention

Keywords

  • Epidemiology
  • Etiology
  • Risk factors
  • Uterine leiomyomata

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Epidemiologic contributions to understanding the etiology of uterine leiomyomata. / Schwartz, Stephen M.; Marshall, Lynn; Baird, Donna D.

In: Environmental Health Perspectives, Vol. 108, No. SUPPL. 5, 2000, p. 821-827.

Research output: Contribution to journalArticle

Schwartz, Stephen M. ; Marshall, Lynn ; Baird, Donna D. / Epidemiologic contributions to understanding the etiology of uterine leiomyomata. In: Environmental Health Perspectives. 2000 ; Vol. 108, No. SUPPL. 5. pp. 821-827.
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