EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls

Robert C. Block, William Harris, Kimberly J. Reid, Scott A. Sands, John A. Spertus

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Background: Increased blood levels of the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been inversely associated with risk for sudden cardiac death, but their relationship with acute coronary syndromes (ACS) is unclear. Objective: We hypothesized that the EPA + DHA content of blood cell membranes, as a percent of total FAs, is reduced in ACS patients relative to matched controls. Methods: We measured the content of EPA + DHA in 768 ACS patients and 768 age-, sex- and race-matched controls. The association with ACS case status of blood cell EPA + DHA [both by a 1 unit change and by category (low,

Original languageEnglish (US)
Pages (from-to)821-828
Number of pages8
JournalAtherosclerosis
Volume197
Issue number2
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Eicosapentaenoic Acid
Docosahexaenoic Acids
Acute Coronary Syndrome
Blood Cells
Cell Membrane
Sudden Cardiac Death
Omega-3 Fatty Acids

Keywords

  • Cardiovascular disease
  • Case-control studies
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. / Block, Robert C.; Harris, William; Reid, Kimberly J.; Sands, Scott A.; Spertus, John A.

In: Atherosclerosis, Vol. 197, No. 2, 04.2008, p. 821-828.

Research output: Contribution to journalArticle

Block, Robert C. ; Harris, William ; Reid, Kimberly J. ; Sands, Scott A. ; Spertus, John A. / EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. In: Atherosclerosis. 2008 ; Vol. 197, No. 2. pp. 821-828.
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