TY - JOUR
T1 - EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls
AU - Block, Robert C.
AU - Harris, William S.
AU - Reid, Kimberly J.
AU - Sands, Scott A.
AU - Spertus, John A.
N1 - Funding Information:
The authors wish to express their appreciation to Karen Nugent, Amy Shipman and Mary Baston for their important contributions in data collection and sample processing, and to Philip Jones for statistical advice. Finally, we are indebted to Dr. James Crockett and the Saint Luke's Hospital Foundation for providing funding for this study.
PY - 2008/4
Y1 - 2008/4
N2 - Background: Increased blood levels of the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been inversely associated with risk for sudden cardiac death, but their relationship with acute coronary syndromes (ACS) is unclear. Objective: We hypothesized that the EPA + DHA content of blood cell membranes, as a percent of total FAs, is reduced in ACS patients relative to matched controls. Methods: We measured the content of EPA + DHA in 768 ACS patients and 768 age-, sex- and race-matched controls. The association with ACS case status of blood cell EPA + DHA [both by a 1 unit change and by category (low, <4%; intermediate 4.1-7.9%; and high, ≥8%)] was assessed using multivariate conditional logistic regression models adjusting for matching variables and smoking status, alcohol use, diabetes, body mass index, serum lipids, education, family history of coronary artery disease, personal histories of myocardial infarction and hypertension, and statin, aspirin, and other antiplatelet drug use. Results: The combined groups had a mean age of 61 ± 12 years, 66% were male, and 92% were Caucasian. The EPA + DHA content was 20% lower in cases than controls (3.4 ± 1.6 vs. 4.25 ± 2.0%, p < 0.001). The multivariable-adjusted odds for case status was 0.77 (95% CI 0.70 to 0.85, p < 0.001) for a 1 unit increase in EPA + DHA content. Compared with the lowest EPA + DHA group, the odds ratio for an ACS event was 0.58 (95% CI 0.42-0.80), in the intermediate EPA + DHA group and was 0.31 (95% CI 0.14-0.67; p for trend <0.0001) in the highest EPA + DHA group. Conclusions: Odds for ACS case status increased incrementally as the EPA + DHA content decreased suggesting that low EPA + DHA may be associated with increased risk for ACS.
AB - Background: Increased blood levels of the omega-3 fatty acids (FA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been inversely associated with risk for sudden cardiac death, but their relationship with acute coronary syndromes (ACS) is unclear. Objective: We hypothesized that the EPA + DHA content of blood cell membranes, as a percent of total FAs, is reduced in ACS patients relative to matched controls. Methods: We measured the content of EPA + DHA in 768 ACS patients and 768 age-, sex- and race-matched controls. The association with ACS case status of blood cell EPA + DHA [both by a 1 unit change and by category (low, <4%; intermediate 4.1-7.9%; and high, ≥8%)] was assessed using multivariate conditional logistic regression models adjusting for matching variables and smoking status, alcohol use, diabetes, body mass index, serum lipids, education, family history of coronary artery disease, personal histories of myocardial infarction and hypertension, and statin, aspirin, and other antiplatelet drug use. Results: The combined groups had a mean age of 61 ± 12 years, 66% were male, and 92% were Caucasian. The EPA + DHA content was 20% lower in cases than controls (3.4 ± 1.6 vs. 4.25 ± 2.0%, p < 0.001). The multivariable-adjusted odds for case status was 0.77 (95% CI 0.70 to 0.85, p < 0.001) for a 1 unit increase in EPA + DHA content. Compared with the lowest EPA + DHA group, the odds ratio for an ACS event was 0.58 (95% CI 0.42-0.80), in the intermediate EPA + DHA group and was 0.31 (95% CI 0.14-0.67; p for trend <0.0001) in the highest EPA + DHA group. Conclusions: Odds for ACS case status increased incrementally as the EPA + DHA content decreased suggesting that low EPA + DHA may be associated with increased risk for ACS.
KW - Cardiovascular disease
KW - Case-control studies
KW - Myocardial infarction
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U2 - 10.1016/j.atherosclerosis.2007.07.042
DO - 10.1016/j.atherosclerosis.2007.07.042
M3 - Article
C2 - 17875307
AN - SCOPUS:40949102602
SN - 0021-9150
VL - 197
SP - 821
EP - 828
JO - Atherosclerosis
JF - Atherosclerosis
IS - 2
ER -