Eosinophils and airway nerves in asthma

R. W. Costello, David Jacoby, G. J. Gleich, Allison Fryer

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

In the lungs, neuronal M2 muscarinic receptors limit the release of acetylcholine from post-ganglionic cholinergic nerves. However, these receptors are not functional under certain circumstances in animal models of hyperreactivity such as occur after exposure of sensitised animals to an allergen or during a respiratory tract virus infection. This loss of M2 receptor function leads to an increase in acetylcholine release from cholinergic nerves and thus is a mechanism for the vagally mediated hyperreactivity seen in these animals. Studies in animal models of hyperreactivity have shown that eosinophils localise to the airway nerves of sensitised animals after antigen challenge. Inhibiting this localisation of eosinophils either with an antibody to the eosinophil survival cytokine IL-5 or the eosinophil adhesion molecule VLA-4 prevents loss of M2 muscarinic receptor function. It is likely that eosinophil MBP is responsible for the loss of M2 receptor function, since inhibiting eosinophil MBP with an antibody or neutralising MBP with heparin prevents this loss of function. These data are also supported by ligand binding studies where it has been shown that eosinophil MBP is an allosteric antagonist at neuronal M2 muscarinic receptors. Loss of function of lung neuronal M2 muscarinic receptors may also occur under certain circumstances in patients with asthma, although the mechanisms are not yet established.

Original languageEnglish (US)
Pages (from-to)861-868
Number of pages8
JournalHistology and Histopathology
Volume15
Issue number3
StatePublished - 2000
Externally publishedYes

Fingerprint

Eosinophils
Muscarinic M2 Receptors
Asthma
Cholinergic Agents
Acetylcholine
Animal Models
Integrin alpha4beta1
Lung
Interleukin-5
Virus Diseases
Neutralizing Antibodies
Respiratory Tract Infections
Allergens
Heparin
Cytokines
Ligands
Antigens
Antibodies

Keywords

  • Hyperresponsiveness
  • Major basic protein
  • Muscarinic receptors
  • Vagus nerves

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Eosinophils and airway nerves in asthma. / Costello, R. W.; Jacoby, David; Gleich, G. J.; Fryer, Allison.

In: Histology and Histopathology, Vol. 15, No. 3, 2000, p. 861-868.

Research output: Contribution to journalArticle

Costello, RW, Jacoby, D, Gleich, GJ & Fryer, A 2000, 'Eosinophils and airway nerves in asthma', Histology and Histopathology, vol. 15, no. 3, pp. 861-868.
Costello, R. W. ; Jacoby, David ; Gleich, G. J. ; Fryer, Allison. / Eosinophils and airway nerves in asthma. In: Histology and Histopathology. 2000 ; Vol. 15, No. 3. pp. 861-868.
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