TY - JOUR
T1 - Eosinophilia-myalgia syndrome associated with L-tryptophan use
AU - Montanaro, A.
AU - Wakefield, D.
PY - 1990
Y1 - 1990
N2 - A young, previously healthy woman presented with increasing muscle pain, lower limb swelling, fatigue and eosinophilia. She had consumed L-tryptophan tablets (one to two at night) over the preceding five months for management of her insomnia. Her condition slowly deteriorated and she developed generalised oedema and severe lethargy. A white blood cell count was 21.3 x 109/L with 43% eosinophils (Normal range: 4.0-11.0 x 109/L with 1-6% eosinophils. A biopsy specimen of the deep fascia and gastrocnemius muscle demonstrated fasciitis and myositis. The patient failed to recover after cessation of L-tryptophan use but her condition improved rapidly without significant sequelae after systemic treatment with corticosteroids.
AB - A young, previously healthy woman presented with increasing muscle pain, lower limb swelling, fatigue and eosinophilia. She had consumed L-tryptophan tablets (one to two at night) over the preceding five months for management of her insomnia. Her condition slowly deteriorated and she developed generalised oedema and severe lethargy. A white blood cell count was 21.3 x 109/L with 43% eosinophils (Normal range: 4.0-11.0 x 109/L with 1-6% eosinophils. A biopsy specimen of the deep fascia and gastrocnemius muscle demonstrated fasciitis and myositis. The patient failed to recover after cessation of L-tryptophan use but her condition improved rapidly without significant sequelae after systemic treatment with corticosteroids.
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U2 - 10.5694/j.1326-5377.1990.tb126157.x
DO - 10.5694/j.1326-5377.1990.tb126157.x
M3 - Article
C2 - 2215340
AN - SCOPUS:0025147428
SN - 0025-729X
VL - 153
SP - 491
EP - 493
JO - Medical Journal of Australia
JF - Medical Journal of Australia
IS - 8
ER -