Eosinophil and airway nerve interactions in asthma

Matthew Drake, Katherine M. Lebold, Quinn R. Roth-Carter, Alexandra B. Pincus, Emily D. Blum, Becky J. Proskocil, David Jacoby, Allison Fryer, Zhenying (Jane) Nie

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalJournal of Leukocyte Biology
Volume104
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Eosinophils
Asthma
Bronchoconstriction
Eosinophil Major Basic Protein
Muscarinic M2 Receptors
Neuropeptides
Reflex
Neurons
Growth

Keywords

  • asthma
  • eosinophil
  • major basic protein
  • parasympathetic nerve
  • sensory nerve

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Drake, M., Lebold, K. M., Roth-Carter, Q. R., Pincus, A. B., Blum, E. D., Proskocil, B. J., ... Nie, Z. J. (2018). Eosinophil and airway nerve interactions in asthma. Journal of Leukocyte Biology, 104(1), 61-67. https://doi.org/10.1002/JLB.3MR1117-426R

Eosinophil and airway nerve interactions in asthma. / Drake, Matthew; Lebold, Katherine M.; Roth-Carter, Quinn R.; Pincus, Alexandra B.; Blum, Emily D.; Proskocil, Becky J.; Jacoby, David; Fryer, Allison; Nie, Zhenying (Jane).

In: Journal of Leukocyte Biology, Vol. 104, No. 1, 01.07.2018, p. 61-67.

Research output: Contribution to journalReview article

Drake, M, Lebold, KM, Roth-Carter, QR, Pincus, AB, Blum, ED, Proskocil, BJ, Jacoby, D, Fryer, A & Nie, ZJ 2018, 'Eosinophil and airway nerve interactions in asthma', Journal of Leukocyte Biology, vol. 104, no. 1, pp. 61-67. https://doi.org/10.1002/JLB.3MR1117-426R
Drake M, Lebold KM, Roth-Carter QR, Pincus AB, Blum ED, Proskocil BJ et al. Eosinophil and airway nerve interactions in asthma. Journal of Leukocyte Biology. 2018 Jul 1;104(1):61-67. https://doi.org/10.1002/JLB.3MR1117-426R
Drake, Matthew ; Lebold, Katherine M. ; Roth-Carter, Quinn R. ; Pincus, Alexandra B. ; Blum, Emily D. ; Proskocil, Becky J. ; Jacoby, David ; Fryer, Allison ; Nie, Zhenying (Jane). / Eosinophil and airway nerve interactions in asthma. In: Journal of Leukocyte Biology. 2018 ; Vol. 104, No. 1. pp. 61-67.
@article{b01bbe89e93c41ea9b454d414699e3a8,
title = "Eosinophil and airway nerve interactions in asthma",
abstract = "Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.",
keywords = "asthma, eosinophil, major basic protein, parasympathetic nerve, sensory nerve",
author = "Matthew Drake and Lebold, {Katherine M.} and Roth-Carter, {Quinn R.} and Pincus, {Alexandra B.} and Blum, {Emily D.} and Proskocil, {Becky J.} and David Jacoby and Allison Fryer and Nie, {Zhenying (Jane)}",
year = "2018",
month = "7",
day = "1",
doi = "10.1002/JLB.3MR1117-426R",
language = "English (US)",
volume = "104",
pages = "61--67",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "FASEB",
number = "1",

}

TY - JOUR

T1 - Eosinophil and airway nerve interactions in asthma

AU - Drake, Matthew

AU - Lebold, Katherine M.

AU - Roth-Carter, Quinn R.

AU - Pincus, Alexandra B.

AU - Blum, Emily D.

AU - Proskocil, Becky J.

AU - Jacoby, David

AU - Fryer, Allison

AU - Nie, Zhenying (Jane)

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.

AB - Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons’ activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils’ effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.

KW - asthma

KW - eosinophil

KW - major basic protein

KW - parasympathetic nerve

KW - sensory nerve

UR - http://www.scopus.com/inward/record.url?scp=85048802270&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048802270&partnerID=8YFLogxK

U2 - 10.1002/JLB.3MR1117-426R

DO - 10.1002/JLB.3MR1117-426R

M3 - Review article

VL - 104

SP - 61

EP - 67

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 1

ER -