Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

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111 Scopus citations

Abstract

A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

Original languageEnglish (US)
Pages (from-to)1257-1259
Number of pages3
JournalBiotechnology Letters
Volume24
Issue number15
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • Alcalase
  • Amino acid
  • Enantiomer
  • Enzymatic resolution
  • Ionic liquid

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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