Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

Hua Zhao; Sanjay V. Malhotra

doi:10.1023/A:1016205924504

Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

Hua Zhao, Sanjay V. Malhotra

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

Original language	English (US)
Pages (from-to)	1257-1259
Number of pages	3
Journal	Biotechnology Letters
Volume	24
Issue number	15
DOIs	https://doi.org/10.1023/A:1016205924504
State	Published - 2002
Externally published	Yes

Keywords

Alcalase
Amino acid
Enantiomer
Enzymatic resolution
Ionic liquid

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/A:1016205924504

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abstract = "A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.",

keywords = "Alcalase, Amino acid, Enantiomer, Enzymatic resolution, Ionic liquid",

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AU - Zhao, Hua

AU - Malhotra, Sanjay V.

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N2 - A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

AB - A new ionic liquid, N-ethyl pyridinium trifluoroacetate, was used with a commercial protease to resolve N-acetyl amino acid esters in place of traditional organic solvents. Products with enantiomeric excess (ee) between 86-97% were obtained. These results show that with low concentration of this new ionic liquid, the enzymatic resolution can be increased considerably depending upon the substrate being used.

KW - Alcalase

KW - Amino acid

KW - Enantiomer

KW - Enzymatic resolution

KW - Ionic liquid

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JO - Biotechnology Letters

JF - Biotechnology Letters

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ER -

Enzymatic resolution of amino acid esters using ionic liquid N-ethyl pyridinium trifluoroacetate

Abstract

Keywords

ASJC Scopus subject areas

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