Environmental exposure to endocrine-disrupting chemicals and miscarriage

Sacha A. Krieg, Lora K. Shahine, Ruth B. Lathi

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Establishment of early pregnancy is the result of complex biochemical interactions between the decidua and blastocyst. Any alteration in this chemical dialogue has the potential to result in adverse pregnancy outcomes including miscarriage. Sporadic miscarriage is the most common complication of pregnancy and can be caused by multiple factors. While the most common cause of miscarriage is genetic abnormalities in the fetus, other contributing factors certainly can play a role in early loss. One such factor is environmental exposure, in particular to endocrine-disrupting chemicals, which has the potential to interfere with endogenous hormone action. These effects can be deleterious, especially in early pregnancy when the hormonal milieu surrounding implantation is in delicate balance. The purpose of this paper is to review the current evidence on the role of environmental toxins in reproduction.

Original languageEnglish (US)
Pages (from-to)941-947
Number of pages7
JournalFertility and sterility
Volume106
Issue number4
DOIs
StatePublished - Sep 15 2016

Keywords

  • Miscarriage
  • endocrine disrupting chemicals
  • environment

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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