Environmental antecedents of young-onset Parkinson's disease

P. G. Butterfield, B. G. Valanis, Peter Spencer, C. A. Lindeman, John Nutt

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

We conducted an exploratory study of young-onset Parkinson's disease (YOPD) to examine occupational and environmental factors associated with disease risk. This case-control study included 63 YOPD patients (diagnosis on or before age 50); controls (n = 68) were diagnosed with rheumatoid arthritis. Crude odds ratios (ORs) were computed to identify exposure variables for logistic regression analyses. After controlling for the variables of race, educational level, sex, age, age at diagnosis, and family history of Parkinson's disease (PD), PD was positively associated with insecticide exposure (OR = 5.75, p <0.001), past residency in a fumigated house (OR = 5.25, p = 0.046), herbicide exposure (OR = 3.22, p = 0.033), rural residency at time of diagnosis (OR = 2.72, p = 0.027), and nuts and seed eating 10 years before diagnosis (OR = 1.49, p = 0.021). PD was inversely associated with cigarette smoking at 5 years (OR = 0.50, p = 0.027), 10 years (OR = 0.43, p = 0.012), and 15 years (OR = 0.37, p = 0.005) before diagnosis, farm residency (OR = 0.38, p = 0.018), and exposure to dimethyl sulfoxide (OR = 0.10, p <0.001). These findings are consistent with hypotheses linking PD to exposure to pesticide agents.

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalNeurology
Volume43
Issue number6
StatePublished - Jun 1993

Fingerprint

Parkinson Disease
Odds Ratio
Internship and Residency
Parkinson's Disease
Onset
Nuts
Herbicides
Insecticides
Dimethyl Sulfoxide
Pesticides
Case-Control Studies
Rheumatoid Arthritis
Seeds
Eating
Logistic Models
Smoking
Regression Analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

Cite this

Butterfield, P. G., Valanis, B. G., Spencer, P., Lindeman, C. A., & Nutt, J. (1993). Environmental antecedents of young-onset Parkinson's disease. Neurology, 43(6), 1150-1158.

Environmental antecedents of young-onset Parkinson's disease. / Butterfield, P. G.; Valanis, B. G.; Spencer, Peter; Lindeman, C. A.; Nutt, John.

In: Neurology, Vol. 43, No. 6, 06.1993, p. 1150-1158.

Research output: Contribution to journalArticle

Butterfield, PG, Valanis, BG, Spencer, P, Lindeman, CA & Nutt, J 1993, 'Environmental antecedents of young-onset Parkinson's disease', Neurology, vol. 43, no. 6, pp. 1150-1158.
Butterfield PG, Valanis BG, Spencer P, Lindeman CA, Nutt J. Environmental antecedents of young-onset Parkinson's disease. Neurology. 1993 Jun;43(6):1150-1158.
Butterfield, P. G. ; Valanis, B. G. ; Spencer, Peter ; Lindeman, C. A. ; Nutt, John. / Environmental antecedents of young-onset Parkinson's disease. In: Neurology. 1993 ; Vol. 43, No. 6. pp. 1150-1158.
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