Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses

Yi Liu, Marcel E. Curlin, Kurt Diem, Hong Zhao, Ananta K. Ghosh, Haiying Zhu, Amanda S. Woodward, Janine Maenza, Claire E. Stevens, Joanne Stekler, Ann C. Collier, Indira Genowati, Wenjie Deng, Rafael Zioni, Lawrence Corey, Tuofu Zhu, James I. Mullins

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Whether there is selection for specific viral Env variants upon HIV-1 transmission is controversial. We examined the V1V2 and V1V4 regions of Env in 10 new and 8 previously described transmission pairs infected with HIV-1 subtype B, including a total of 9 pairs in which the infecting partner had developed substantial viral diversity prior to transmission. We found that during transmission of HIV-1 subtype B, as well as for other subtypes reported in the past, viral populations in recipients undergo substantial genetic bottlenecks, as well as weak evidence for a propensity to replicate viruses with shorter variable loops and fewer potential N-linked glycosylation sites.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalVirology
Volume374
Issue number2
DOIs
StatePublished - May 10 2008

Keywords

  • Env sequence length
  • HIV-1
  • N-linked glycosylation sites
  • Primary infection
  • Transmission

ASJC Scopus subject areas

  • Virology

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    Liu, Y., Curlin, M. E., Diem, K., Zhao, H., Ghosh, A. K., Zhu, H., Woodward, A. S., Maenza, J., Stevens, C. E., Stekler, J., Collier, A. C., Genowati, I., Deng, W., Zioni, R., Corey, L., Zhu, T., & Mullins, J. I. (2008). Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses. Virology, 374(2), 229-233. https://doi.org/10.1016/j.virol.2008.01.029