Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats

Hariharan Sankaran, Georgia C. Baba, Clifford Deveney, G. Ananda Rao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Rats fed the Lieber-DeCarli 36% alcohol diet ad libitum exhibit alcoholemia. Since 36% of carbohydrate (CHO) calories in the control diet are replaced with alcohol, the alcoholic rats ingest low levels of CHO. Furthermore, alcoholic rats ingest 40-50% less calories when compared to rats fed the control diet ad libitum. The present study was carried out to determine the effect of providing marginal additional energy on blood alcohol levels (BAL) in alcoholic rats. Four groups of rats implanted with intragastric cannulae were allowed to ingest orally the alcohol diet ad libitum, and either water (two control groups, one each for CHO and protein) or additional calories, as either maltose-dextrin or casein, were continously infused through the cannulae. All four groups of rats consumed similar amounts of alcohol; however, water-infused rats exhibited high BAL. The BAL in the two nutrient-infused groups were insignificant. These data demonstrate that BAL can be regulated by nutritional means in rats consuming doses of alcohol high enough to cause alcoholemia.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalNutrition Research
Volume11
Issue number2-3
DOIs
StatePublished - 1991

Fingerprint

Small Intestine
Alcohols
Diet
Blood Alcohol Content
Maltose
Water
Caseins
Carbohydrates
Food
Control Groups

Keywords

  • blood alcohol levels
  • Intragastric infusion
  • liquid alcohol diet
  • macronutrients
  • nutritional adequacy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats. / Sankaran, Hariharan; Baba, Georgia C.; Deveney, Clifford; Rao, G. Ananda.

In: Nutrition Research, Vol. 11, No. 2-3, 1991, p. 217-222.

Research output: Contribution to journalArticle

Sankaran, Hariharan ; Baba, Georgia C. ; Deveney, Clifford ; Rao, G. Ananda. / Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats. In: Nutrition Research. 1991 ; Vol. 11, No. 2-3. pp. 217-222.
@article{a6cd72ab51bb459b87c6f87be9821481,
title = "Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats",
abstract = "Rats fed the Lieber-DeCarli 36{\%} alcohol diet ad libitum exhibit alcoholemia. Since 36{\%} of carbohydrate (CHO) calories in the control diet are replaced with alcohol, the alcoholic rats ingest low levels of CHO. Furthermore, alcoholic rats ingest 40-50{\%} less calories when compared to rats fed the control diet ad libitum. The present study was carried out to determine the effect of providing marginal additional energy on blood alcohol levels (BAL) in alcoholic rats. Four groups of rats implanted with intragastric cannulae were allowed to ingest orally the alcohol diet ad libitum, and either water (two control groups, one each for CHO and protein) or additional calories, as either maltose-dextrin or casein, were continously infused through the cannulae. All four groups of rats consumed similar amounts of alcohol; however, water-infused rats exhibited high BAL. The BAL in the two nutrient-infused groups were insignificant. These data demonstrate that BAL can be regulated by nutritional means in rats consuming doses of alcohol high enough to cause alcoholemia.",
keywords = "blood alcohol levels, Intragastric infusion, liquid alcohol diet, macronutrients, nutritional adequacy",
author = "Hariharan Sankaran and Baba, {Georgia C.} and Clifford Deveney and Rao, {G. Ananda}",
year = "1991",
doi = "10.1016/S0271-5317(05)80121-6",
language = "English (US)",
volume = "11",
pages = "217--222",
journal = "Nutrition Research",
issn = "0271-5317",
publisher = "Elsevier Inc.",
number = "2-3",

}

TY - JOUR

T1 - Enteral macronutrients abolish high blood alcohol levels in chronic alcoholic rats

AU - Sankaran, Hariharan

AU - Baba, Georgia C.

AU - Deveney, Clifford

AU - Rao, G. Ananda

PY - 1991

Y1 - 1991

N2 - Rats fed the Lieber-DeCarli 36% alcohol diet ad libitum exhibit alcoholemia. Since 36% of carbohydrate (CHO) calories in the control diet are replaced with alcohol, the alcoholic rats ingest low levels of CHO. Furthermore, alcoholic rats ingest 40-50% less calories when compared to rats fed the control diet ad libitum. The present study was carried out to determine the effect of providing marginal additional energy on blood alcohol levels (BAL) in alcoholic rats. Four groups of rats implanted with intragastric cannulae were allowed to ingest orally the alcohol diet ad libitum, and either water (two control groups, one each for CHO and protein) or additional calories, as either maltose-dextrin or casein, were continously infused through the cannulae. All four groups of rats consumed similar amounts of alcohol; however, water-infused rats exhibited high BAL. The BAL in the two nutrient-infused groups were insignificant. These data demonstrate that BAL can be regulated by nutritional means in rats consuming doses of alcohol high enough to cause alcoholemia.

AB - Rats fed the Lieber-DeCarli 36% alcohol diet ad libitum exhibit alcoholemia. Since 36% of carbohydrate (CHO) calories in the control diet are replaced with alcohol, the alcoholic rats ingest low levels of CHO. Furthermore, alcoholic rats ingest 40-50% less calories when compared to rats fed the control diet ad libitum. The present study was carried out to determine the effect of providing marginal additional energy on blood alcohol levels (BAL) in alcoholic rats. Four groups of rats implanted with intragastric cannulae were allowed to ingest orally the alcohol diet ad libitum, and either water (two control groups, one each for CHO and protein) or additional calories, as either maltose-dextrin or casein, were continously infused through the cannulae. All four groups of rats consumed similar amounts of alcohol; however, water-infused rats exhibited high BAL. The BAL in the two nutrient-infused groups were insignificant. These data demonstrate that BAL can be regulated by nutritional means in rats consuming doses of alcohol high enough to cause alcoholemia.

KW - blood alcohol levels

KW - Intragastric infusion

KW - liquid alcohol diet

KW - macronutrients

KW - nutritional adequacy

UR - http://www.scopus.com/inward/record.url?scp=0025890085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025890085&partnerID=8YFLogxK

U2 - 10.1016/S0271-5317(05)80121-6

DO - 10.1016/S0271-5317(05)80121-6

M3 - Article

AN - SCOPUS:0025890085

VL - 11

SP - 217

EP - 222

JO - Nutrition Research

JF - Nutrition Research

SN - 0271-5317

IS - 2-3

ER -