Enolase autoantibodies and retinal function in multiple sclerosis patients

Farzin Forooghian, Grazyna Adamus, Melanie Sproule, Carol Westall, Paul O'Connor

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Electroretinographic (ERG) abnormalities have been reported in multiple sclerosis (MS), as well as the presence of circulating antiretinal antibodies. We and others have reported cases of impaired vision and diminished ERGs in MS patients with α-enolase autoantibodies. Anti-enolase antibodies have been implicated in autoimmune retinopathy. We performed this study to further explore the relationship between antiretinal antibodies and ERG changes in patients with MS. Methods: Patients with clinically definite MS and normal visual acuity were recruited for this study, along with healthy controls. All patients and controls had ERG testing done according to ISCEV standards. Patient and control sera were analyzed for the presence of antiretinal antibodies using Western blot and ELISA techniques, and HLA class II typing was performed using polymerase chain reaction. Results: We found a statistically significant difference between MS patients and controls in the rod-cone b-wave implicit time (p

Original languageEnglish (US)
Pages (from-to)1077-1084
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume245
Issue number8
DOIs
StatePublished - Aug 2007

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Phosphopyruvate Hydratase
Autoantibodies
Multiple Sclerosis
Antibodies
Low Vision
Vertebrate Photoreceptor Cells
Visual Acuity
Anti-Idiotypic Antibodies
Western Blotting
Enzyme-Linked Immunosorbent Assay
Polymerase Chain Reaction
Serum

Keywords

  • Autoimmunity
  • Electroretinogram
  • Enolase
  • Multiple sclerosis
  • Retina

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Enolase autoantibodies and retinal function in multiple sclerosis patients. / Forooghian, Farzin; Adamus, Grazyna; Sproule, Melanie; Westall, Carol; O'Connor, Paul.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 245, No. 8, 08.2007, p. 1077-1084.

Research output: Contribution to journalArticle

Forooghian, Farzin ; Adamus, Grazyna ; Sproule, Melanie ; Westall, Carol ; O'Connor, Paul. / Enolase autoantibodies and retinal function in multiple sclerosis patients. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 2007 ; Vol. 245, No. 8. pp. 1077-1084.
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