TY - JOUR
T1 - Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis
AU - Wooliscroft, Lindsey
AU - Boespflug, Erin
AU - Hildebrand, Andrea
AU - Shangraw, Kathleen
AU - Silbermann, Elizabeth
AU - Bourdette, Dennis
AU - Spain, Rebecca
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Department of Veterans Affairs (B7493-W, R. Spain), NIH (UL1TR000128). Dr. Wooliscroft is supported by K23HD101667 from the National Institutes of Health (NIH). Dr. Silbermann is supported by NMSS Sylvia Lawry Fellowship. Dr. Boespflug was supported by K01AG059842 and P30AG008017 from the NIH.
PY - 2020
Y1 - 2020
N2 - Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.
AB - Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.
KW - atrophy
KW - biomarkers
KW - MRI
KW - multiple sclerosis
KW - outcome measurement
KW - progressive
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U2 - 10.1177/2055217320964502
DO - 10.1177/2055217320964502
M3 - Article
AN - SCOPUS:85092556494
SN - 2055-2173
VL - 6
JO - Multiple Sclerosis Journal - Experimental, Translational and Clinical
JF - Multiple Sclerosis Journal - Experimental, Translational and Clinical
IS - 4
ER -