Enlarged perivascular spaces are not associated with vascular co-morbidities, clinical outcomes, and brain volumes in people with secondary progressive multiple sclerosis

Lindsey Wooliscroft, Erin Boespflug, Andrea Hildebrand, Kathleen Shangraw, Elizabeth Silbermann, Dennis Bourdette, Rebecca Spain

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In secondary progressive multiple sclerosis (SPMS) significance of enlarged perivascular spaces (ePVS) is unknown. Objectives, Methods: Analysis of associations between vascular co-morbidities, clinical outcomes, and volumetrics with categorical ePVS scores in midbrain, basal ganglia (BG), and centrum semiovale (CSO) in SPMS(n-46). Results, Conclusion: In BG, advancing age (Z = 2.68) and lower Expanded Disability Status Scale (Z = −2.04) were associated with increasing ePVS score. In CSO, advancing age (Z = 2.66) and male gender (Z = 2.45) were associated with increasing ePVS score. No associations between ePVS score and vascular co-morbidities or volumetrics existed; ePVS may not be an informative marker for SPMS.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal - Experimental, Translational and Clinical
Volume6
Issue number4
DOIs
StatePublished - 2020

Keywords

  • atrophy
  • biomarkers
  • MRI
  • multiple sclerosis
  • outcome measurement
  • progressive

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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