Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Z. G. Jiang; M. A. Simmons; N. J. Dun

doi:10.1016/0006-8993(82)90211-6

Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Z. G. Jiang, M. A. Simmons, N. J. Dun

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

Original language	English (US)
Pages (from-to)	185-191
Number of pages	7
Journal	Brain research
Volume	235
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(82)90211-6
State	Published - Mar 4 1982
Externally published	Yes

Keywords

enkephalin
presynaptic modulation
substance P

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(82)90211-6

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title = "Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia",

abstract = "The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.",

keywords = "enkephalin, presynaptic modulation, substance P",

author = "Jiang, {Z. G.} and Simmons, {M. A.} and Dun, {N. J.}",

note = "Funding Information: We wish to thank Dr. S. A. Shefner for helpful discussion. This study was supported in part by NIH Grant NS15848.",

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AU - Jiang, Z. G.

AU - Simmons, M. A.

AU - Dun, N. J.

N1 - Funding Information: We wish to thank Dr. S. A. Shefner for helpful discussion. This study was supported in part by NIH Grant NS15848.

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Y1 - 1982/3/4

N2 - The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

AB - The non-cholinergic excitatory potential elicited in neurons of the isolated inferior mesentric ganglia was depressed by bath application of Met- and Leu-enkephalin and enhanced by naloxone or naltrexone. The membrane depolarization induced by exogenously applied putative transmitter substance P was not appreciably affected by either enkephalin (Enk) or opiate antagonists. Our results indicate that the non-cholinergic excitatory transmission which may be mediated by substance P in prevertebral ganglia is modulated presynaptically by endogenously released Enk in a manner that may resemble the interaction between these two peptides in the spinal cord.

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KW - presynaptic modulation

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Enkephalinergic modulation of non-cholinergic transmission in mammalian prevertebral ganglia

Abstract

Keywords

ASJC Scopus subject areas

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