Enkephalin blocks inhibitory pathways in the vertebrate CNS

R. A. Nicoll, B. E. Alger, Craig Jahr

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254 Scopus citations


Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
Issue number5777
Publication statusPublished - 1980
Externally publishedYes


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Nicoll, R. A., Alger, B. E., & Jahr, C. (1980). Enkephalin blocks inhibitory pathways in the vertebrate CNS. Nature, 287(5777), 22-25. https://doi.org/10.1038/287022a0