Enkephalin blocks inhibitory pathways in the vertebrate CNS

R. A. Nicoll; B. E. Alger; C. E. Jahr

doi:10.1038/287022a0

Enkephalin blocks inhibitory pathways in the vertebrate CNS

R. A. Nicoll, B. E. Alger, C. E. Jahr

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Abstract

Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.

Original language	English (US)
Pages (from-to)	22-25
Number of pages	4
Journal	Nature
Volume	287
Issue number	5777
DOIs	https://doi.org/10.1038/287022a0
State	Published - 1980
Externally published	Yes

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title = "Enkephalin blocks inhibitory pathways in the vertebrate CNS",

abstract = "Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.",

author = "Nicoll, {R. A.} and Alger, {B. E.} and Jahr, {C. E.}",

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AB - Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.

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Enkephalin blocks inhibitory pathways in the vertebrate CNS

Abstract

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