Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging

Ahmet Erten, David Hall, Carl Hoh, Hop S. Tran Cao, Sharmeela Kaushal, Sadik Esener, Robert M. Hoffman, Michael Bouvet, James Chen, Santosh Kesari, Milan Makale

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Early detection is important for many solid cancers but the images provided by ultrasound, magnetic resonance imaging (MRI), and computed tomography applied alone or together, are often not sufficient for decisive early screeningdiagnosis. We demonstrate that MRI augmented with fluorescence intensity (FI) substantially improves detection. Early stage murine pancreatic tumors that could not be identified by blinded, skilled observers using MRI alone, were easily identified with MRI along with FI images acquired with photomultiplier tube detection and offset laser scanning. Moreover, we show that fluorescence lifetime (FLT) imaging enables positive identification of the labeling fluorophore and discriminates it from surrounding tissue autofluorescence. Our data suggest combined-modality imaging with MRI, FI, and FLT can be used to screen and diagnose early tumors.

Original languageEnglish (US)
Article number066012
JournalJournal of biomedical optics
Volume15
Issue number6
DOIs
StatePublished - Nov 2010

Keywords

  • cancer detection
  • fluorescence intensity imaging
  • magnetic resonance imaging
  • orthopedic models
  • pancreatic cancer
  • red fluorescent protein

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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  • Cite this

    Erten, A., Hall, D., Hoh, C., Tran Cao, H. S., Kaushal, S., Esener, S., Hoffman, R. M., Bouvet, M., Chen, J., Kesari, S., & Makale, M. (2010). Enhancing magnetic resonance imaging tumor detection with fluorescence intensity and lifetime imaging. Journal of biomedical optics, 15(6), [066012]. https://doi.org/10.1117/1.3509111