@article{2744834d1bfe4eeda0aaed5eb78336c9,
title = "Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging",
abstract = "The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 ?m depth and 31% enhancement in image depth Zthreshold.",
keywords = "Chemical penetration enhancer, Optical clearing, Optical coherence tomography, Physical massage",
author = "Xiang Wen and Jacques, {Steven L.} and Tuchin, {Valery V.} and Dan Zhu",
note = "Funding Information: The authors are thankful to A. N. Bashkatov, E. A. Genina, N. A. Trunina, and O. V. Glushkovskaya-Semyachkina from SSU for their help in providing experiments. Dan Zhu is thankful for the support of the grants of the National Nature Science Foundation of China (No. 81171376), and the Research Fund for the Doctoral Program of Higher Education of China (No. 20110142110073). Valery V. Tuchin and Dan Zhu appreciate the support of their collaboration by grant NSFC-RFBR for the International Cooperation (No. 30911120074) and RFBR-08-02-92224-NNSF_a (RF—China). Valery V. Tuchin is thankful for the support of grants 224014 Photonics4life-FP7-ICT-2007-2; RF 2.1.1/4989, 2.2.1.1/2950,1.4.09; and RF Governmental contract 02.740.11.0879. RF 1.4.09; RF Governmental contract 02.740.11.0879; and FiDiPro, TEKES (40111/11), Finland.",
year = "2012",
month = jun,
doi = "10.1117/1.JBO.17.6.066022",
language = "English (US)",
volume = "17",
journal = "Journal of biomedical optics",
issn = "1083-3668",
publisher = "SPIE",
number = "6",
}