Enhanced optical clearing of skin in vivo and optical coherence tomography in-depth imaging

Xiang Wen, Steven L. Jacques, Valery V. Tuchin, Dan Zhu

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The strong optical scattering of skin tissue makes it very difficult for optical coherence tomography (OCT) to achieve deep imaging in skin. Significant optical clearing of in vivo rat skin sites was achieved within 15 min by topical application of an optical clearing agent PEG-400, a chemical enhancer (thiazone or propanediol), and physical massage. Only when all three components were applied together could a 15 min treatment achieve a three fold increase in the OCT reflectance from a 300 ?m depth and 31% enhancement in image depth Zthreshold.

Original languageEnglish (US)
Article number066022
JournalJournal of biomedical optics
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • Chemical penetration enhancer
  • Optical clearing
  • Optical coherence tomography
  • Physical massage

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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