Enhanced neural activation with blueberry supplementation in mild cognitive impairment

Erin Boespflug, James C. Eliassen, Jonathan A. Dudley, Marcelle D. Shidler, Wilhelmina Kalt, Suzanne S. Summer, Amanda L. Stein, Amanda N. Stover, Robert Krikorian

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objectives: Preclinical studies have shown that blueberry supplementation can improve cognitive performance and neural function in aged animals and have identified associations between anthocyanins and such benefits. Preliminary human trials also suggest cognitive improvement in older adults, although direct evidence of enhancement of brain function has not been demonstrated. In this study, we investigated the effect of blueberry supplementation on regional brain activation in older adults at risk for dementia. Methods: In a randomized, double-blind, placebo-controlled trial we performed pre- and post-intervention functional magnetic resonance imaging during a working memory (WM) task to assess the effect of blueberry supplementation on blood oxygen level-dependent (BOLD) signal in older adults with mild cognitive impairment, a risk condition for dementia. Results: Following daily supplementation for 16 weeks, blueberry-treated participants exhibited increased BOLD activation in the left pre-central gyrus, left middle frontal gyrus, and left inferior parietal lobe during WM load conditions (corrected P < 0.01). There was no clear indication of WM enhancement associated with blueberry supplementation. Diet records indicated no between-group difference in anthocyanin consumption external to the intervention. Discussion: These data demonstrate, for the first time, enhanced neural response during WM challenge in blueberry-treated older adults with cognitive decline and are consistent with prior trials showing neurocognitive benefit with blueberry supplementation in this at-risk population.

Original languageEnglish (US)
Pages (from-to)297-305
Number of pages9
JournalNutritional Neuroscience
Volume21
Issue number4
DOIs
StatePublished - Apr 21 2018
Externally publishedYes

Fingerprint

Blueberry Plants
Short-Term Memory
Anthocyanins
Dementia
Oxygen
Diet Records
Parietal Lobe
Brain
Cognitive Dysfunction
Prefrontal Cortex
Placebos
Magnetic Resonance Imaging

Keywords

  • Aging
  • Blueberries
  • Brain activation
  • Dementia
  • fMRI
  • MCI

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Boespflug, E., Eliassen, J. C., Dudley, J. A., Shidler, M. D., Kalt, W., Summer, S. S., ... Krikorian, R. (2018). Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutritional Neuroscience, 21(4), 297-305. https://doi.org/10.1080/1028415X.2017.1287833

Enhanced neural activation with blueberry supplementation in mild cognitive impairment. / Boespflug, Erin; Eliassen, James C.; Dudley, Jonathan A.; Shidler, Marcelle D.; Kalt, Wilhelmina; Summer, Suzanne S.; Stein, Amanda L.; Stover, Amanda N.; Krikorian, Robert.

In: Nutritional Neuroscience, Vol. 21, No. 4, 21.04.2018, p. 297-305.

Research output: Contribution to journalArticle

Boespflug, E, Eliassen, JC, Dudley, JA, Shidler, MD, Kalt, W, Summer, SS, Stein, AL, Stover, AN & Krikorian, R 2018, 'Enhanced neural activation with blueberry supplementation in mild cognitive impairment', Nutritional Neuroscience, vol. 21, no. 4, pp. 297-305. https://doi.org/10.1080/1028415X.2017.1287833
Boespflug, Erin ; Eliassen, James C. ; Dudley, Jonathan A. ; Shidler, Marcelle D. ; Kalt, Wilhelmina ; Summer, Suzanne S. ; Stein, Amanda L. ; Stover, Amanda N. ; Krikorian, Robert. / Enhanced neural activation with blueberry supplementation in mild cognitive impairment. In: Nutritional Neuroscience. 2018 ; Vol. 21, No. 4. pp. 297-305.
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