Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice

Sean M. Baker, Allie C. Harris, Jen Lan Tsao, Tom J. Flath, C. Eric Bronner, Melissa Gordon, Darryl Shibata, Robert (Mike) Liskay

Research output: Contribution to journalArticle

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Abstract

Analysis of two human familial cancer syndromes, hereditary nonpolyposis colorectal cancer and familial adenomatous polyposis, indicates that mutations in either one of four DNA mismatch repair gene homologues or the adenomatous polyposis coli (APC) gene, respectively, are important for the development of colorectal cancer. To further investigate the role of DNA mismatch repair in intestinal tumorigenesis, we generated mice with mutations in both Apc and the DNA mismatch repair gene, Pms2. Whereas Pms2-deficient mice do not develop intestinal tumors, mice deficient in Pms2 and heterozygous for Min, an allele of Apc, develop approximately three times the number of small intestinal adenomas and four times the number of colon adenomas relative to Min and Pms2(+/-); Min mice. Although Pms2 deficiency dearly increases adenoma formation in the Min background, histological analysis indicated no clear evidence for progression to carcinoma.

Original languageEnglish (US)
Pages (from-to)1087-1089
Number of pages3
JournalCancer Research
Volume58
Issue number6
StatePublished - Mar 15 1998

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Intestinal Polyps
Adenomatous Polyps
DNA Mismatch Repair
Adenoma
APC Genes
Hereditary Nonpolyposis Colorectal Neoplasms
Mutation
Adenomatous Polyposis Coli
Genes
Colorectal Neoplasms
Neoplasms
Colon
Carcinogenesis
Alleles
Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Baker, S. M., Harris, A. C., Tsao, J. L., Flath, T. J., Bronner, C. E., Gordon, M., ... Liskay, R. M. (1998). Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice. Cancer Research, 58(6), 1087-1089.

Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice. / Baker, Sean M.; Harris, Allie C.; Tsao, Jen Lan; Flath, Tom J.; Bronner, C. Eric; Gordon, Melissa; Shibata, Darryl; Liskay, Robert (Mike).

In: Cancer Research, Vol. 58, No. 6, 15.03.1998, p. 1087-1089.

Research output: Contribution to journalArticle

Baker, SM, Harris, AC, Tsao, JL, Flath, TJ, Bronner, CE, Gordon, M, Shibata, D & Liskay, RM 1998, 'Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice', Cancer Research, vol. 58, no. 6, pp. 1087-1089.
Baker SM, Harris AC, Tsao JL, Flath TJ, Bronner CE, Gordon M et al. Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice. Cancer Research. 1998 Mar 15;58(6):1087-1089.
Baker, Sean M. ; Harris, Allie C. ; Tsao, Jen Lan ; Flath, Tom J. ; Bronner, C. Eric ; Gordon, Melissa ; Shibata, Darryl ; Liskay, Robert (Mike). / Enhanced intestinal adenomatous polyp formation in Pms2(-/-);Min mice. In: Cancer Research. 1998 ; Vol. 58, No. 6. pp. 1087-1089.
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