Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

E. R. Peskind; M. A. Raskind; D. Wingerson; M. Pascualy; L. J. Thal; D. J. Dobie; R. C. Veith; D. M. Dorsa; S. Murray; C. Sikkema; S. A. Galt; C. W. Wilkinson

doi:10.1093/gerona/50A.2.M114

Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

E. R. Peskind, M. A. Raskind, D. Wingerson, M. Pascualy, L. J. Thal, D. J. Dobie, R. C. Veith, D. M. Dorsa, S. Murray, C. Sikkema, S. A. Galt, C. W. Wilkinson

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Abstract

Background. The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity. Methods. Plasma ACTH, beta- endorphin (βE) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 ± 2 years [mean ± SEM]) and 9 normal young subjects (27 ± 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups. Results. Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p < .01), βE (p < .01) and cortisol (p < .01). Plasma physostigmine concentrations did not differ between older and young subjects. Conclusion. This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.

Original language	English (US)
Pages (from-to)	M114-M120
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	50
Issue number	2
DOIs	https://doi.org/10.1093/gerona/50A.2.M114
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1093/gerona/50A.2.M114

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Peskind, E. R., Raskind, M. A., Wingerson, D., Pascualy, M., Thal, L. J., Dobie, D. J., Veith, R. C., Dorsa, D. M., Murray, S., Sikkema, C., Galt, S. A., & Wilkinson, C. W. (1995). Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 50(2), M114-M120. https://doi.org/10.1093/gerona/50A.2.M114

Peskind, ER, Raskind, MA, Wingerson, D, Pascualy, M, Thal, LJ, Dobie, DJ, Veith, RC, Dorsa, DM, Murray, S, Sikkema, C, Galt, SA & Wilkinson, CW 1995, 'Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 50, no. 2, pp. M114-M120. https://doi.org/10.1093/gerona/50A.2.M114

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abstract = "Background. The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity. Methods. Plasma ACTH, beta- endorphin (βE) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 ± 2 years [mean ± SEM]) and 9 normal young subjects (27 ± 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups. Results. Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p < .01), βE (p < .01) and cortisol (p < .01). Plasma physostigmine concentrations did not differ between older and young subjects. Conclusion. This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.",

author = "Peskind, {E. R.} and Raskind, {M. A.} and D. Wingerson and M. Pascualy and Thal, {L. J.} and Dobie, {D. J.} and Veith, {R. C.} and Dorsa, {D. M.} and S. Murray and C. Sikkema and Galt, {S. A.} and Wilkinson, {C. W.}",

year = "1995",

doi = "10.1093/gerona/50A.2.M114",

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AU - Peskind, E. R.

AU - Raskind, M. A.

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AU - Pascualy, M.

AU - Thal, L. J.

AU - Dobie, D. J.

AU - Veith, R. C.

AU - Dorsa, D. M.

AU - Murray, S.

AU - Sikkema, C.

AU - Galt, S. A.

AU - Wilkinson, C. W.

PY - 1995

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N2 - Background. The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity. Methods. Plasma ACTH, beta- endorphin (βE) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 ± 2 years [mean ± SEM]) and 9 normal young subjects (27 ± 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups. Results. Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p < .01), βE (p < .01) and cortisol (p < .01). Plasma physostigmine concentrations did not differ between older and young subjects. Conclusion. This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.

AB - Background. The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity. Methods. Plasma ACTH, beta- endorphin (βE) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 ± 2 years [mean ± SEM]) and 9 normal young subjects (27 ± 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups. Results. Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p < .01), βE (p < .01) and cortisol (p < .01). Plasma physostigmine concentrations did not differ between older and young subjects. Conclusion. This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.

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Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

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