Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging

E. R. Peskind, M. A. Raskind, D. Wingerson, M. Pascualy, L. J. Thal, D. J. Dobie, R. C. Veith, Daniel Dorsa, S. Murray, C. Sikkema, S. A. Galt, C. W. Wilkinson

Research output: Contribution to journalArticle

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Abstract

Background. The purpose of this study was to determine the effects of normal human aging on the hypothalamic-pituitary-adrenocortical (HPA) axis response to the centrally active cholinesterase inhibitor physostigmine. This drug stimulates the HPA axis at a suprapituitary level by increasing central nervous system (CNS) cholinergic activity. Methods. Plasma ACTH, beta- endorphin (βE) and cortisol responses to a 10-minute infusion of physostigmine (.0125 mg/kg) were compared between groups of 10 normal older subjects (71 ± 2 years [mean ± SEM]) and 9 normal young subjects (27 ± 2 years). Plasma physostigmine concentrations were measured to assess the comparability of the pharmacologic stimulus between groups. Results. Endocrine responses were substantially greater in older subjects than young subjects for ACTH (p <.01), βE (p <.01) and cortisol (p <.01). Plasma physostigmine concentrations did not differ between older and young subjects. Conclusion. This study demonstrated increased HPA axis responsivity to a CNS cholinergic stimulus in normal human aging.

Original languageEnglish (US)
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume50
Issue number2
StatePublished - 1995
Externally publishedYes

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Physostigmine
Adrenocorticotropic Hormone
Cholinergic Agents
Hydrocortisone
Central Nervous System
beta-Endorphin
Cholinesterase Inhibitors
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Aging

Cite this

Peskind, E. R., Raskind, M. A., Wingerson, D., Pascualy, M., Thal, L. J., Dobie, D. J., ... Wilkinson, C. W. (1995). Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 50(2).

Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging. / Peskind, E. R.; Raskind, M. A.; Wingerson, D.; Pascualy, M.; Thal, L. J.; Dobie, D. J.; Veith, R. C.; Dorsa, Daniel; Murray, S.; Sikkema, C.; Galt, S. A.; Wilkinson, C. W.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 50, No. 2, 1995.

Research output: Contribution to journalArticle

Peskind, ER, Raskind, MA, Wingerson, D, Pascualy, M, Thal, LJ, Dobie, DJ, Veith, RC, Dorsa, D, Murray, S, Sikkema, C, Galt, SA & Wilkinson, CW 1995, 'Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 50, no. 2.
Peskind, E. R. ; Raskind, M. A. ; Wingerson, D. ; Pascualy, M. ; Thal, L. J. ; Dobie, D. J. ; Veith, R. C. ; Dorsa, Daniel ; Murray, S. ; Sikkema, C. ; Galt, S. A. ; Wilkinson, C. W. / Enhanced hypothalamic-pituitary-adrenocortical axis responses to physostigmine in normal aging. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 1995 ; Vol. 50, No. 2.
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