Engineering Biomimetic Materials for Skeletal Muscle Repair and Regeneration

Karina H. Nakayama, Mahdis Shayan, Ngan F. Huang

Research output: Contribution to journalReview articlepeer-review

70 Scopus citations


Although skeletal muscle is highly regenerative following injury or disease, endogenous self-regeneration is severely impaired in conditions of volume traumatic muscle loss. Consequently, tissue engineering approaches are a promising means to regenerate skeletal muscle. Biological scaffolds serve as not only structural support for the promotion of cellular ingrowth but also impart potent modulatory signaling cues that may be beneficial for tissue regeneration. In this work, the progress of tissue engineering approaches for skeletal muscle engineering and regeneration is overviewed, with a focus on the techniques to create biomimetic engineered tissue using extracellular cues. These factors include mechanical and electrical stimulation, geometric patterning, and delivery of growth factors or other bioactive molecules. The progress of evaluating the therapeutic efficacy of these approaches in preclinical models of muscle injury is further discussed.

Original languageEnglish (US)
Article number1801168
JournalAdvanced Healthcare Materials
Issue number5
StatePublished - Mar 7 2019
Externally publishedYes


  • biomaterials
  • skeletal muscle regeneration
  • spatial patterning
  • volumetric muscle loss

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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