Abstract
Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P
| Original language | English (US) |
|---|---|
| Pages (from-to) | 380-385 |
| Number of pages | 6 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 175 |
| Issue number | 3 |
| State | Published - 1984 |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
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Endotoxin shock : Prevented by naloxone in intact but not hypophysectomized rats (41810). / Davis, S. D.; McDonald, W. J.; Kendall, John; Potter, D. M.
In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 175, No. 3, 1984, p. 380-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endotoxin shock
T2 - Prevented by naloxone in intact but not hypophysectomized rats (41810)
AU - Davis, S. D.
AU - McDonald, W. J.
AU - Kendall, John
AU - Potter, D. M.
PY - 1984
Y1 - 1984
N2 - Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P
AB - Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P
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UR - http://www.scopus.com/inward/citedby.url?scp=0021146821&partnerID=8YFLogxK
M3 - Article
C2 - 6320213
AN - SCOPUS:0021146821
VL - 175
SP - 380
EP - 385
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
SN - 1535-3702
IS - 3
ER -