Endotoxin shock: Prevented by naloxone in intact but not hypophysectomized rats (41810)

S. D. Davis, W. J. McDonald, John Kendall, D. M. Potter

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume175
Issue number3
StatePublished - 1984

Fingerprint

Naloxone
Endotoxins
Rats
Shock
Catheters
Hypotension
Endorphins
Hemorrhagic Shock
Blood pressure
Arterial Pressure
Neck
Stabilization
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Endotoxin shock : Prevented by naloxone in intact but not hypophysectomized rats (41810). / Davis, S. D.; McDonald, W. J.; Kendall, John; Potter, D. M.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 175, No. 3, 1984, p. 380-385.

Research output: Contribution to journalArticle

Davis, S. D. ; McDonald, W. J. ; Kendall, John ; Potter, D. M. / Endotoxin shock : Prevented by naloxone in intact but not hypophysectomized rats (41810). In: Proceedings of the Society for Experimental Biology and Medicine. 1984 ; Vol. 175, No. 3. pp. 380-385.
@article{460efb5fffc64b89af352f9d31825c5f,
title = "Endotoxin shock: Prevented by naloxone in intact but not hypophysectomized rats (41810)",
abstract = "Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P",
author = "Davis, {S. D.} and McDonald, {W. J.} and John Kendall and Potter, {D. M.}",
year = "1984",
language = "English (US)",
volume = "175",
pages = "380--385",
journal = "Experimental Biology and Medicine",
issn = "1535-3702",
publisher = "SAGE Publications Ltd",
number = "3",

}

TY - JOUR

T1 - Endotoxin shock

T2 - Prevented by naloxone in intact but not hypophysectomized rats (41810)

AU - Davis, S. D.

AU - McDonald, W. J.

AU - Kendall, John

AU - Potter, D. M.

PY - 1984

Y1 - 1984

N2 - Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P

AB - Previous studies established that naloxone reverses hypotension in endotoxin, hemorrhagic, and spinal shock. We studied endotoxin shock in hypophysectomized (Hx) rats, which have little circulating β-endorphin. Hx or intact rats received surgically implanted jugular catheters for drug injection and aortic catheters for arterial blood pressure (MAP) recording. On the second day after implantation, rats were pretreated with either naloxone or saline. Two minutes later each rat received endotoxin. Following endotoxin, all rats showed a brief biphasic hypertensive-hypotensive response followed by stabilization of MAP near baseline. Within 20 min, all Hx rats, regardless of pretreatment, and the saline-treated intact rats, showed progressive hypotension (P

UR - http://www.scopus.com/inward/record.url?scp=0021146821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021146821&partnerID=8YFLogxK

M3 - Article

C2 - 6320213

AN - SCOPUS:0021146821

VL - 175

SP - 380

EP - 385

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

SN - 1535-3702

IS - 3

ER -