Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

Kurt A. Heldwein, Janet E. Duncan, Peter Stenzel, Marvin B. Rittenberg, Mary P. Stenzel-Poore

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume131
Issue number2
DOIs
StatePublished - Aug 8 1997

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Keywords

  • Corticotropin-releasing hormone
  • Endotoxin
  • Heart
  • Receptor
  • Regulation
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology

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