Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

Kurt A. Heldwein; Janet E. Duncan; Peter Stenzel; Marvin B. Rittenberg; Mary P. Stenzel-Poore

doi:10.1016/S0303-7207(97)00103-2

Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

Kurt A. Heldwein, Janet E. Duncan, Peter Stenzel, Marvin B. Rittenberg, Mary P. Stenzel-Poore

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35 Scopus citations

Abstract

We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

Original language	English (US)
Pages (from-to)	167-172
Number of pages	6
Journal	Molecular and Cellular Endocrinology
Volume	131
Issue number	2
DOIs	https://doi.org/10.1016/S0303-7207(97)00103-2
State	Published - Aug 8 1997

Keywords

Corticotropin-releasing hormone
Endotoxin
Heart
Receptor
Regulation
Skeletal muscle

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/S0303-7207(97)00103-2

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title = "Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle",

abstract = "We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.",

keywords = "Corticotropin-releasing hormone, Endotoxin, Heart, Receptor, Regulation, Skeletal muscle",

author = "Heldwein, {Kurt A.} and Duncan, {Janet E.} and Peter Stenzel and Rittenberg, {Marvin B.} and Stenzel-Poore, {Mary P.}",

note = "Funding Information: We thank Giselle Crosa and Dana Redick for technical assistance. This work was supported by NIH grants AI14985 and AI26827 (MBR) and MH52393 (MS-P), an American Heart Association Oregon Affiliate grant (MS-P) and by NIH/NEI predoctoral training grant 2T32EY07123 (KAH).",

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doi = "10.1016/S0303-7207(97)00103-2",

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AU - Heldwein, Kurt A.

AU - Duncan, Janet E.

AU - Stenzel, Peter

AU - Rittenberg, Marvin B.

AU - Stenzel-Poore, Mary P.

N1 - Funding Information: We thank Giselle Crosa and Dana Redick for technical assistance. This work was supported by NIH grants AI14985 and AI26827 (MBR) and MH52393 (MS-P), an American Heart Association Oregon Affiliate grant (MS-P) and by NIH/NEI predoctoral training grant 2T32EY07123 (KAH).

PY - 1997/8/8

Y1 - 1997/8/8

N2 - We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

AB - We tested the effect of endotoxin on the peripheral corticotropin-releasing hormone receptor (CRH-R2), which is highly expressed in the heart. Systemic injection of LPS markedly downregulated CRH-R2 mRNA levels in the heart in a dose and time dependent manner. In contrast, CRH-R2 levels in skeletal muscle increased following exposure to endotoxin. These results suggest that CRH-R2 may be differentially regulated in cardiac tissue and skeletal muscle. Finding that CRH-R2 expression in the heart is modulated by endotoxin, a potent inducer of cardiovascular dysregulation, suggests a possible link between CRH and the cardiovascular response to stress.

KW - Corticotropin-releasing hormone

KW - Endotoxin

KW - Heart

KW - Receptor

KW - Regulation

KW - Skeletal muscle

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Endotoxin regulates corticotropin-releasing hormone receptor 2 in heart and skeletal muscle

Abstract

Keywords

ASJC Scopus subject areas

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