Endothelium-derived hyperpolarizing factor in the brain: Influence of sex, vessel size and disease state

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

The endothelial layer of cells lining the intimal surface of blood vessels is essential for vascular function. The endothelium releases multiple vasodilator and protective factors, including nitric oxide, prostacyclin and endothelium-derived hyperpolarizing factor; an imbalance in these factors predisposes individuals to vascular diseases such as stroke. These factors are differentially regulated by vessel size, sex hormones and disease state, therefore playing differential roles in different tissues following vascular injury. In particular, the endothelium-derived hyperpolarizing factor candidate termed epoxyeicosatrienoic acid, plays a prominent role in microvessel function, especially after ischemia, thereby making this signaling pathway an attractive target for therapy in vascular disease, including stroke.

Original languageEnglish (US)
Pages (from-to)293-303
Number of pages11
JournalWomen's Health
Volume7
Issue number3
DOIs
StatePublished - May 2011

Keywords

  • EDHF
  • EET
  • cerebrovascular
  • endothelial
  • endothelium-derived hyperpolarizing factor
  • epoxyeicosatrienoic acid
  • ischemia
  • vasodilation

ASJC Scopus subject areas

  • Medicine(all)

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