Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation

Leslie Myatt, Gretchen Langdon, Anthony S. Brewer, Diane E. Brockman

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The vasoconstrictor peptide endothelin-1 (8 × 10-10 to 1 × 10-8 mol/L) significantly increased fetal-placental perfusion pressure in vitro in a cumulative manner from 30 ± 2 to 123 ± 25 mm Hg (mean ± SEM, n = 5, p <0.0005, analysis of variance). Accompanying this vasoconstriction was a corresponding reduction in fetal-placental perfusate flow rate. Measurement of thromboxane B2 and 6-keto-prostaglandin F in the fetal-placental perfusate revealed a significant reduction in their release (p <0.0096 and p <0.0004, analysis of variance, respectively) when corrected for flow rate. Neither the thromboxane synthesis inhibitor dazoxiben (10-6 mol/L) nor the thromboxane receptor antagonist SO29548 (10-6 mol/L) was able to block the vasoconstrictor actions of endothelin-1. Therefore endothelin-1-induced vasoconstriction in the human fetal-placental circulation does not appear to be mediated by thromboxane release or action. The stimulus to eicosanoid release in the fetal-placental circulation may be hydrodynamic, i.e., flow or shear stress.

Original languageEnglish (US)
Pages (from-to)1717-1722
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume165
Issue number6 PART 1
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Placental Circulation
Thromboxanes
Endothelin-1
Vasoconstriction
Vasoconstrictor Agents
Analysis of Variance
Multifetal Pregnancy Reduction
Thromboxane Receptors
Thromboxane B2
Eicosanoids
Hydrodynamics
Perfusion
Pressure
Peptides

Keywords

  • Endothelin
  • hromboxane
  • placenta
  • vasoconstriction

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Endothelin-1-induced vasoconstriction is not mediated by thromboxane release and action in the human fetal-placental circulation. / Myatt, Leslie; Langdon, Gretchen; Brewer, Anthony S.; Brockman, Diane E.

In: American Journal of Obstetrics and Gynecology, Vol. 165, No. 6 PART 1, 1991, p. 1717-1722.

Research output: Contribution to journalArticle

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