Endothelial outgrowth cells

Function and performance in vascular grafts

Jeremy J. Glynn, Monica Hinds

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The clinical need for vascular grafts continues to grow. Tissue engineering strategies have been employed to develop vascular grafts for patients lacking sufficient autologous vessels for grafting. Restoring a functional endothelium on the graft lumen has been shown to greatly improve the long-term patency of small-diameter grafts. However, obtaining an autologous source of endothelial cells for in vitro endothelialization is invasive and often not a viable option. Endothelial outgrowth cells (EOCs), derived from circulating progenitor cells in peripheral blood, provide an alternative cell source for engineering an autologous endothelium. This review aims at highlighting the role of EOCs in the regulation of processes that are central to vascular graft performance. To characterize EOC performance in vascular grafts, this review identifies the characteristics of EOCs, defines functional performance criteria for EOCs in vascular grafts, and summarizes the existing work in developing vascular grafts with EOCs.

Original languageEnglish (US)
Pages (from-to)294-303
Number of pages10
JournalTissue Engineering - Part B: Reviews
Volume20
Issue number4
DOIs
StatePublished - Aug 1 2014

Fingerprint

Grafts
Blood Vessels
Endothelial Cells
Transplants
Endothelium
Cell Engineering
Endothelial cells
Tissue Engineering
Tissue engineering
Blood
Stem Cells

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Bioengineering
  • Biochemistry
  • Medicine(all)

Cite this

Endothelial outgrowth cells : Function and performance in vascular grafts. / Glynn, Jeremy J.; Hinds, Monica.

In: Tissue Engineering - Part B: Reviews, Vol. 20, No. 4, 01.08.2014, p. 294-303.

Research output: Contribution to journalArticle

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