Endoscopic ultrasound may be unnecessary in the preoperative evaluation of intraductal papillary mucinous neoplasm

Molly M. Cone, Jennifer D. Rea, Brian S. Diggs, Kevin Billingsley, Brett Sheppard

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Several imaging modalities are commonly performed during work-up of intraductal papillary mucinous neoplasm (IPMN), but guidelines do not suggest any one technique. The aim of this study was to evaluate tumour and duct measurements by computed tomography (CT) and endoscopic ultrasound (EUS) and their ability to predict high-grade dysplasia (HGD) and cancer within pancreatic IPMN. Methods: Patients with IPMN who underwent preoperative CT and EUS between 2001 and 2009 were selected. Data were gathered retrospectively from medical records. Results: The study group was comprised of 52 patients, 33% (17/52) of whom had HGD or cancer. On fine needle aspirate (FNA), neither carcinoembryonic antigen (CEA) >200 nor cytological analysis correlated with malignancy. In multivariate analysis, duct size ≥1.0 cm (P= 0.034) was a significant predictor of HGD or cancer, and diameter on CT scan (P= 0.056) approached significance. Lesion diameter of ≥ 2.5 cm on CT scan identified malignancy in 71% (12/17) of patients (P= 0.037). When analysed, all patients with HGD or cancer had a lesion diameter ≥2.5 cm and/or a duct diameter ≥1.0 cm by CT scan. Conclusions: The use of radiographic criteria on CT including lesion size ≥2.5 cm and/or pancreatic duct diameter ≥1.0 cm appears to reliably identify patients with either HGD or invasive cancer. High-resolution CT scanning may obviate the need for EUS and FNA in patients with suspected IPMN.

Original languageEnglish (US)
Pages (from-to)112-116
Number of pages5
JournalHPB
Volume13
Issue number2
DOIs
StatePublished - Feb 2011

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Tomography
Neoplasms
Needles
Pancreatic Ducts
Carcinoembryonic Antigen
Pancreatic Neoplasms
Medical Records
Multivariate Analysis
Guidelines

Keywords

  • computed tomography
  • endoscopic ultrasound
  • intraductal papillary mucinous neoplasm
  • malignancy
  • pancreas

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Endoscopic ultrasound may be unnecessary in the preoperative evaluation of intraductal papillary mucinous neoplasm. / Cone, Molly M.; Rea, Jennifer D.; Diggs, Brian S.; Billingsley, Kevin; Sheppard, Brett.

In: HPB, Vol. 13, No. 2, 02.2011, p. 112-116.

Research output: Contribution to journalArticle

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