Endoscopic Sclerotherapy for Esophageal Variceal Hemorrhage

Robert S. Gordon, Bennett M. Derby, John P. Cello, James H. Grendell, Richard A. Crass, Donald D. Trunkey, Thorkild I.a. Sørensen, Peter Matzen, Flemming Burcharth, Bjørn Andersen

Research output: Contribution to journalLetterpeer-review

2 Scopus citations

Abstract

To the Editor: How could the Journal, which six years earlier published a landmark paper on the need for adequate sample size in controlled clinical trials,1 now publish without comment the paper by Cello et al. (Dec. 20 issue),2 which overinterprets the negative results of a trial based on a very modest number of patients? These authors randomly assigned 52 patients to one of two alternative forms of treatment and “failed to demonstrate any significant difference in long-term survival. …” They go on to state that “acute and vigorously repeated endoscopic sclerotherapy is at least as good as, and.

Original languageEnglish (US)
Pages (from-to)989-990
Number of pages2
JournalNew England Journal of Medicine
Volume312
Issue number15
DOIs
StatePublished - Apr 11 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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