Endoscopic palliative treatment in pancreatic cancer

K. Huibregtse, Ronald Katon, P. P. Coene, G. N J Tytgat

Research output: Contribution to journalArticle

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Abstract

Patients with carcinoma of the head of the pancreas will develop obstructive jaundice at some point in their course in 80% to 90% of the cases. Surgical biliary digestive anastomosis carries a high 30-day mortality (20%), and hospitalization may be prolonged for several weeks owing to postoperative morbidity. We attempted endoscopic endoprosthesis placement in 221 patients with pancreatic carcinoma for palliation of obstructive jaundice. The procedure was successful in 200 of 221 (90%) with a procedure-related mortality of only 2% and a 30-day mortality of 10%. The serum bilirubin level normalized in 92% of those who survived, and the mean survival of 6 months is comparable to that achieved with biliodigestive anastomosis. Early cholangitis (8%) and late clogging of the endoprosthesis (21% at a mean of 5 months) are problem areas that need to be improved. We believe these results justify considering endoscopic biliary prosthesis as the treatment of choice in nonresectable jaundiced patients with carcinoma of the head of the pancreas.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalGastrointestinal Endoscopy
Volume32
Issue number5
StatePublished - 1986

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Pancreatic Neoplasms
Palliative Care
Obstructive Jaundice
Mortality
Pancreas
Carcinoma
Cholangitis
Jaundice
Bilirubin
Prostheses and Implants
Hospitalization
Morbidity
Survival
Serum
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Huibregtse, K., Katon, R., Coene, P. P., & Tytgat, G. N. J. (1986). Endoscopic palliative treatment in pancreatic cancer. Gastrointestinal Endoscopy, 32(5), 334-338.

Endoscopic palliative treatment in pancreatic cancer. / Huibregtse, K.; Katon, Ronald; Coene, P. P.; Tytgat, G. N J.

In: Gastrointestinal Endoscopy, Vol. 32, No. 5, 1986, p. 334-338.

Research output: Contribution to journalArticle

Huibregtse, K, Katon, R, Coene, PP & Tytgat, GNJ 1986, 'Endoscopic palliative treatment in pancreatic cancer', Gastrointestinal Endoscopy, vol. 32, no. 5, pp. 334-338.
Huibregtse K, Katon R, Coene PP, Tytgat GNJ. Endoscopic palliative treatment in pancreatic cancer. Gastrointestinal Endoscopy. 1986;32(5):334-338.
Huibregtse, K. ; Katon, Ronald ; Coene, P. P. ; Tytgat, G. N J. / Endoscopic palliative treatment in pancreatic cancer. In: Gastrointestinal Endoscopy. 1986 ; Vol. 32, No. 5. pp. 334-338.
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