Endoscopic measurement of cardia circumference as an indicator of GERD

Ann K. Seltman, Peter J. Kahrilas, Eugene Y. Chang, Motomi (Tomi) Mori, John Hunter, Blair A. Jobe

Research output: Contribution to journalArticle

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Abstract

Background: It is theorized that repeated gastric distention leads to dilatation of the cardia and the development of GERD. We hypothesize that cardia circumference correlates with the presence and the severity of GERD, and we developed software to measure cardia circumference from static endoscopic images. Our aims were to validate the software and to quantify cardia circumference along the spectrum of GERD. Methods: Software-based measurements were compared with actual measurements in animal and mechanical models. A retrospective review of an endoscopic database and patient charts produced 273 subjects, grouped as follows: controls, GERD, ≤3-cm Barrett's esophagus, or >3-cm Barrett's esophagus. A blinded abstractor measured cardia circumference by using images from the database. Results: Software and actual measurements correlated closely and were reproducible among observers. Median cardia circumference for each group was the following: control, 31.8 mm; GERD, 37.8 mm; ≤3-cm Barrett's esophagus, 38.4 mm; and >3-cm Barrett's esophagus, 45.0 mm (p <0.001). By using 34.3 mm as a cutoff, cardia circumference was 85.3% sensitive and 89.6% specific for the diagnosis of GERD. Conclusions: There was a direct relationship between cardia circumference and the presence of GERD. This finding augments our understanding of the anatomic contributions of the esophagogastric junction in the pathogenesis of GERD. Cardia measurement may prove to be a useful diagnostic tool.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalGastrointestinal Endoscopy
Volume63
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Cardia
Gastroesophageal Reflux
Barrett Esophagus
Software
Databases
Esophagogastric Junction
Dilatation
Stomach
Animal Models

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic measurement of cardia circumference as an indicator of GERD. / Seltman, Ann K.; Kahrilas, Peter J.; Chang, Eugene Y.; Mori, Motomi (Tomi); Hunter, John; Jobe, Blair A.

In: Gastrointestinal Endoscopy, Vol. 63, No. 1, 01.2006, p. 22-31.

Research output: Contribution to journalArticle

Seltman, Ann K. ; Kahrilas, Peter J. ; Chang, Eugene Y. ; Mori, Motomi (Tomi) ; Hunter, John ; Jobe, Blair A. / Endoscopic measurement of cardia circumference as an indicator of GERD. In: Gastrointestinal Endoscopy. 2006 ; Vol. 63, No. 1. pp. 22-31.
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