Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: Preliminary experience

Fergus V. Coakley, Seong Teh Hui, Aliya Qayyum, Mark G. Swanson, Ying Lu, Mack Roach, Barby Pickett, Katsuto Shinohara, Daniel B. Vigneron, John Kurhanewicz

Research output: Contribution to journalReview article

183 Scopus citations

Abstract

PURPOSE: To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy. MATERIALS AND METHODS: Endorectal MR imaging and MR spectroscopic imaging were performed in 21 patients with biochemical failure after external beam radiation therapy for prostate cancer. Two readers independently and retrospectively reviewed MR images and rated the likelihood of recurrent tumor on a five-point scale. Spectroscopic voxels were considered suspicious for malignancy if the choline level was elevated and citrate was absent. Receiver operating characteristic curve analysis was used to assess cancer detection in each side of the prostate with endorectal MR imaging and spectroscopic imaging at different thresholds based on the scores assigned by the two readers and on the number of suspicious voxels in each hemiprostate, respectively. The presence or absence of cancer at subsequent transrectal biopsy was used as the standard of reference. RESULTS: Biopsy demonstrated locally recurrent prostate cancer in nine hemiprostates in six patients. The area under the receiver operating characteristic curve for the detection of locally recurrent cancer with MR imaging was 0.49 and 0.51 for readers 1 and 2, respectively. By using the number of suspicious voxels to define different diagnostic thresholds, the area under the receiver operating characteristic curve for MR spectroscopic imaging was significantly (P < .005) higher, at 0.81. In particular, the presence of three or more suspicious voxels in a hemiprostate showed a sensitivity and specificity of 89% and 82%, respectively, for the diagnosis of local recurrence. Seven hemiprostates demonstrated complete metabolic atrophy at spectroscopic imaging and only postirradiation atrophy at biopsy. CONCLUSION: Preliminary data suggest that MR spectroscopic imaging, but not endorectal MR imaging, may be of value for the depiction of locally recurrent prostate cancer after radiation therapy.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalRADIOLOGY
Volume233
Issue number2
DOIs
StatePublished - Nov 1 2004

Keywords

  • Magnetic resonance (MR), spectroscopy, 844.12145
  • Prostate neoplasms, MR, 844.121411, 844.12145
  • Radiation therapy, 844.1299

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Coakley, F. V., Hui, S. T., Qayyum, A., Swanson, M. G., Lu, Y., Roach, M., Pickett, B., Shinohara, K., Vigneron, D. B., & Kurhanewicz, J. (2004). Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: Preliminary experience. RADIOLOGY, 233(2), 441-448. https://doi.org/10.1148/radiol.2332032086