Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1

Varsha Singh, Alejandro Aballay

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In response to pathogen infection, the host innate immune system activates microbial killing pathways and cellular stress pathways that need to be balanced because insufficient or excessive immune responses have deleterious consequences. Recent studies demonstrate that two G protein-coupled receptors (GPCRs) in the nervous system of Caenorhabditis elegans control immune homeostasis. To investigate further how GPCR signaling controls immune homeostasis at the organismal level, we studied arrestin-1 (ARR-1), which is the only GPCR adaptor protein in C. elegans. The results indicate that ARR-1 is required for GPCR signaling in ASH, ASI, AQR, PQR, and URX neurons, which control the unfolded protein response and a p38 mitogen-activated protein kinase signaling pathway required for innate immunity. ARR-1 activity also controlled immunity through ADF chemosensory and AFD thermosensory neurons that regulate longevity. Furthermore, we found that although ARR-1 played a key role in the control of immunity by AFD thermosensory neurons, it did not control longevity through these cells. However, ARR-1 partially controlled longevity through ADF neurons.

Original languageEnglish (US)
Pages (from-to)33191-33197
Number of pages7
JournalJournal of Biological Chemistry
Volume287
Issue number40
DOIs
StatePublished - Sep 28 2012
Externally publishedYes

Fingerprint

Arrestin
Endoplasmic Reticulum Stress
G-Protein-Coupled Receptors
Homeostasis
Neurons
Immunity
Caenorhabditis elegans Proteins
Unfolded Protein Response
Immune system
Caenorhabditis elegans
Neurology
p38 Mitogen-Activated Protein Kinases
Pathogens
Innate Immunity
Nervous System
Immune System
Proteins
Infection

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Endoplasmic reticulum stress pathway required for immune homeostasis is neurally controlled by arrestin-1. / Singh, Varsha; Aballay, Alejandro.

In: Journal of Biological Chemistry, Vol. 287, No. 40, 28.09.2012, p. 33191-33197.

Research output: Contribution to journalArticle

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