Endometriosis and endometriosis-associated ovarian cancer (EAOC)

Tanja Pejovic, Sarah Thisted, Michael White, Farr R. Nezhat

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Endometriosis is a gynecologic disease that affects over 10% of women of reproductive age causing pelvic pain, dysmenorrhea, and infertility, resulting in significant disability and reduced quality of life. Very recent genetic studies have suggested that endometriosis is a clonal disease in the epithelium and its development is independent of stroma, providing new insight into the genesis of endometriosis. The endometrioid tissue lining may also react by epithelial atypical hyperplasia and even neoplasia, in a manner somehow similar to that in the uterine cavity and under the same hormonal influences.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages73-87
Number of pages15
DOIs
StatePublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1242
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Endometriosis
  • Genetics
  • Histology
  • Management
  • Pathophysiology
  • Surveillance
  • Treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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