Endogenous ANG II supports lumbar sympathetic activity in conscious sodium-deprived rats

Role of area postrema

Ling Xu, John P. Collister, John W. Osborn, Virginia Brooks

Research output: Contribution to journalArticle

Abstract

This study tests the hypothesis that the area postrema (AP) is necessary for endogenous ANG II to chronically maintain lumbar sympathetic nerve activity (LSNA) and heart rate (HR) in conscious sodium-deprived rats. The effect of the ANG II type 1-receptor antagonist, losartan, on LSNA and HR was determined in rats that were either AP lesioned (APX) or sham lesioned. The sham rats were divided into groups, with (SFR) or without (SAL) food restriction, to control for the decreased food intake of APX rats. Before losartan, basal mean arterial pressure (MAP), HR, and baroreflex control of LSNA and HR were similar between groups, with the exception of lower maximal reflex LSNA and higher maximal gain of the HR-MAP curve in APX rats. In all groups, losartan similarly shifted (P

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume275
Issue number1 44-1
StatePublished - Jul 1998

Fingerprint

Area Postrema
Heart Rate
Sodium
Losartan
Arterial Pressure
Baroreflex
Reflex
Eating
Food

Keywords

  • Angiotensin II type 1 receptor
  • Baroreflex
  • Heart rate
  • Losartan
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Physiology

Cite this

@article{5a86ca6fac3d4fd1a7afd047fd011ce8,
title = "Endogenous ANG II supports lumbar sympathetic activity in conscious sodium-deprived rats: Role of area postrema",
abstract = "This study tests the hypothesis that the area postrema (AP) is necessary for endogenous ANG II to chronically maintain lumbar sympathetic nerve activity (LSNA) and heart rate (HR) in conscious sodium-deprived rats. The effect of the ANG II type 1-receptor antagonist, losartan, on LSNA and HR was determined in rats that were either AP lesioned (APX) or sham lesioned. The sham rats were divided into groups, with (SFR) or without (SAL) food restriction, to control for the decreased food intake of APX rats. Before losartan, basal mean arterial pressure (MAP), HR, and baroreflex control of LSNA and HR were similar between groups, with the exception of lower maximal reflex LSNA and higher maximal gain of the HR-MAP curve in APX rats. In all groups, losartan similarly shifted (P",
keywords = "Angiotensin II type 1 receptor, Baroreflex, Heart rate, Losartan, Sympathetic nerve activity",
author = "Ling Xu and Collister, {John P.} and Osborn, {John W.} and Virginia Brooks",
year = "1998",
month = "7",
language = "English (US)",
volume = "275",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "1 44-1",

}

TY - JOUR

T1 - Endogenous ANG II supports lumbar sympathetic activity in conscious sodium-deprived rats

T2 - Role of area postrema

AU - Xu, Ling

AU - Collister, John P.

AU - Osborn, John W.

AU - Brooks, Virginia

PY - 1998/7

Y1 - 1998/7

N2 - This study tests the hypothesis that the area postrema (AP) is necessary for endogenous ANG II to chronically maintain lumbar sympathetic nerve activity (LSNA) and heart rate (HR) in conscious sodium-deprived rats. The effect of the ANG II type 1-receptor antagonist, losartan, on LSNA and HR was determined in rats that were either AP lesioned (APX) or sham lesioned. The sham rats were divided into groups, with (SFR) or without (SAL) food restriction, to control for the decreased food intake of APX rats. Before losartan, basal mean arterial pressure (MAP), HR, and baroreflex control of LSNA and HR were similar between groups, with the exception of lower maximal reflex LSNA and higher maximal gain of the HR-MAP curve in APX rats. In all groups, losartan similarly shifted (P

AB - This study tests the hypothesis that the area postrema (AP) is necessary for endogenous ANG II to chronically maintain lumbar sympathetic nerve activity (LSNA) and heart rate (HR) in conscious sodium-deprived rats. The effect of the ANG II type 1-receptor antagonist, losartan, on LSNA and HR was determined in rats that were either AP lesioned (APX) or sham lesioned. The sham rats were divided into groups, with (SFR) or without (SAL) food restriction, to control for the decreased food intake of APX rats. Before losartan, basal mean arterial pressure (MAP), HR, and baroreflex control of LSNA and HR were similar between groups, with the exception of lower maximal reflex LSNA and higher maximal gain of the HR-MAP curve in APX rats. In all groups, losartan similarly shifted (P

KW - Angiotensin II type 1 receptor

KW - Baroreflex

KW - Heart rate

KW - Losartan

KW - Sympathetic nerve activity

UR - http://www.scopus.com/inward/record.url?scp=0031814208&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031814208&partnerID=8YFLogxK

M3 - Article

VL - 275

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 1 44-1

ER -