Endocrine profile of pregnancy in the patas monkey (Erythrocebus patas)

Jorg Winterer, Amos E. Palmer, John Cicmanec, Edward Davis, Steven Harbaugh, D. Lynn Loriaux

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Spontaneous toxemia occurs in approximately 6% of pregnancies in patas monkeys (Erythrocebus patas). To assess further the relevance of this animal as a model system for toxemia of pregnancy in humans, we characterized the endocrine profile of the patas pregnancy by analyzing weekly blood samples for estrone, estradiol, estriol, progesterone, aldosterone, and PRA throughout gestation. The profiles obtained bear striking resemblance to those described for human pregnancy, an unexpected finding since the patas monkey is not a higher hominoid. We conclude that the patas monkey may provide a model of toxemia relevant to study of the human disorder and is superior to other animal models which require surgical manipulation and are characterized by secondary hyperreninemia.

Original languageEnglish (US)
Pages (from-to)1090-1093
Number of pages4
JournalEndocrinology
Volume116
Issue number3
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Endocrinology

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