Endocardially Derived Macrophages Are Essential for Valvular Remodeling

Ayako Shigeta; Vincent Huang; Jonathan Zuo; Rana Besada; Yasuhiro Nakashima; Yan Lu; Yichen Ding; Matteo Pellegrini; Rajan P. Kulkarni; Tzung Hsiai; Arjun Deb; Bin Zhou; Haruko Nakano; Atsushi Nakano

doi:10.1016/j.devcel.2019.01.021

Endocardially Derived Macrophages Are Essential for Valvular Remodeling

Ayako Shigeta, Vincent Huang, Jonathan Zuo, Rana Besada, Yasuhiro Nakashima, Yan Lu, Yichen Ding, Matteo Pellegrini, Rajan P. Kulkarni, Tzung Hsiai, Arjun Deb, Bin Zhou, Haruko Nakano, Atsushi Nakano

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.

Original language	English (US)
Pages (from-to)	617-630.e3
Journal	Developmental Cell
Volume	48
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2019.01.021
State	Published - Mar 11 2019
Externally published	Yes

Keywords

cardiac tissue macrophage
cardiogenesis
congenital heart disease
hematopoiesis
hemogenic endocardium
multipotent cardiac progenitor cells
tissue macrophages
valve disease
valve remodeling
valvulogenesis

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.01.021

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title = "Endocardially Derived Macrophages Are Essential for Valvular Remodeling",

abstract = "Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.",

keywords = "cardiac tissue macrophage, cardiogenesis, congenital heart disease, hematopoiesis, hemogenic endocardium, multipotent cardiac progenitor cells, tissue macrophages, valve disease, valve remodeling, valvulogenesis",

author = "Ayako Shigeta and Vincent Huang and Jonathan Zuo and Rana Besada and Yasuhiro Nakashima and Yan Lu and Yichen Ding and Matteo Pellegrini and Kulkarni, {Rajan P.} and Tzung Hsiai and Arjun Deb and Bin Zhou and Haruko Nakano and Atsushi Nakano",

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year = "2019",

month = mar,

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doi = "10.1016/j.devcel.2019.01.021",

language = "English (US)",

volume = "48",

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journal = "Developmental Cell",

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T1 - Endocardially Derived Macrophages Are Essential for Valvular Remodeling

AU - Shigeta, Ayako

AU - Huang, Vincent

AU - Zuo, Jonathan

AU - Besada, Rana

AU - Nakashima, Yasuhiro

AU - Lu, Yan

AU - Ding, Yichen

AU - Pellegrini, Matteo

AU - Kulkarni, Rajan P.

AU - Hsiai, Tzung

AU - Deb, Arjun

AU - Zhou, Bin

AU - Nakano, Haruko

AU - Nakano, Atsushi

PY - 2019/3/11

Y1 - 2019/3/11

N2 - Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.

AB - Shigeta et al. found that a subset of macrophages in the heart valves originates locally from the fetal endocardium. This local type of macrophages is more phagocytic than other macrophages and critical for the valve remodeling during cardiogenesis.

KW - cardiac tissue macrophage

KW - cardiogenesis

KW - congenital heart disease

KW - hematopoiesis

KW - hemogenic endocardium

KW - multipotent cardiac progenitor cells

KW - tissue macrophages

KW - valve disease

KW - valve remodeling

KW - valvulogenesis

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DO - 10.1016/j.devcel.2019.01.021

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SN - 1534-5807

VL - 48

SP - 617-630.e3

JO - Developmental Cell

JF - Developmental Cell

IS - 5

ER -

Endocardially Derived Macrophages Are Essential for Valvular Remodeling

Abstract

Keywords

ASJC Scopus subject areas

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