Endocannabinoids Mediate Synaptic Plasticity at Mixed Synapses

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Abstract

Endocannabinoids are generally known to suppress excitatory or inhibitory synaptic transmission. Now, in an elegant series of experiments, Cachope et al. reveal a novel signaling pathway whereby endocannabinoids indirectly potentiate mixed chemical and electrical synapses. Gap junction-mediated transmission can thus be potentiated via distinct frequency-dependent mechanisms.

Original languageEnglish (US)
Pages (from-to)945-946
Number of pages2
JournalNeuron
Volume56
Issue number6
DOIs
StatePublished - Dec 20 2007

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ASJC Scopus subject areas

  • Neuroscience(all)

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