Pênfigo endêmico na amazônia peruana: Epidemiologia e fatores de risco para o desenvolvimento de complicações durante o tratamento

Translated title of the contribution: Endemic pemphigus in the Peruvian Amazon: Epidemiology and risk factors for the development of complications during treatment

Willy Ramos, Gina Rocio Chacon, Carlos Galarza, Ericson Leonardo Gutierrez, Maria Eugenia Smith, Alex Ortega Loayza

Research output: Contribution to journalArticle

9 Scopus citations


BACKGROUND: Pemphigus is an autoimmune blistering disease. According to a report, in areas of endemic pemphigus foliaceus (EPF) in Peru there are cases of pemphigus vulgaris with epidemiologic, clinical and histopathologic characteristics similar to those of endemic pemphigus vulgaris (EPV) in Brazil. OBJECTIVES: To determine the clinical and epidemiologic characteristics of endemic pemphigus and the risk factors of patients for developing complications during treatment. METHODS: A study was carried out from July 2003 to March 2008. The study population was 60 patients with EPF and 7 patients with EPV evaluated in hospitals and clinics in the Peruvian Amazon and Lima. A multivariate analysis was carried out using binary logistic regression. RESULTS: The average age of EPF patients was 31.4 years; 55% were men; 60% presented the generalized clinical variant. Non-compliance with the treatment was seen in 57.1% of the patients. Thirty-five percent presented complications (e.g. pyodermitis and pyelonephritis) during treatment. The risk factors for developing complications during treatment were non-compliance with the treatment and having the generalized clinical form. In the EPV group, the average age was 21.7 years; 71.4% were men. All patients presented with the mucocutaneous clinical variant and the initial presentation consisted of oral mucosa lesions; 71.4% presented complications during treatment, pyodermitis being the most frequent. CONCLUSIONS: Non-compliance with the treatment and the generalized clinical form are risk factors for the development of complications during treatment of patients with EPF. Peru indeed has EPV cases with epidemiologic characteristics similar to EPF. Living in a rural area may represent a risk factor for the development of complications during treatment of patients with EPV.

Original languagePortuguese
Pages (from-to)838-845
Number of pages8
JournalAnais Brasileiros de Dermatologia
Issue number6
Publication statusPublished - Nov 1 2012
Externally publishedYes



  • Epidemiology
  • Pemphigus
  • Peru

ASJC Scopus subject areas

  • Dermatology

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