Endemic pemphigus foliaceus in the Peruvian Amazon

Alex Ortega Loayza, W. Ramos, E. L. Gutierrez, G. Jimenez, I. Rojas, C. Galarza

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background Endemic pemphigus foliaceus (EPF) is an organ-specific blistering disease of the epidermis characterized by the presence of IgG autoantibodies, specifically desmoglein (Dsg)1. This condition has been reported particularly in Brazil, Colombia, Tunisia and Peru. Aim To characterize the humoral response against Dsg1 and Dsg3 autoantibodies of patients with EPF from the Peruvian Amazon region. Methods Blood samples were collected from 16 patients with a clinical diagnosis of EPF, and tested using indirect immunofluorescence (IIF), immunoprecipitation and ELISA (for IgG and its subclasses against Dsg1 and IgG against Dsg3). Results Autoantibodies against the intercellular spaces were detected by IIF in 82.5% and 87.5% of patients, using normal human skin and monkey oesophagus, respectively. Sera from all patients immunoprecipitated recombinant Dsg1, and three serum samples immunoprecipitated recombinant Dsg3 (6.25%). Using ELISA, anti-Dsg1 antibodies were detected in 13 patients (81.25%), and both IgG1 and IgG2 antibodies against Dsg1 in 12 patients (75%). All patients were positive for IgG4 autoantibodies, and only one patient was positive for IgG3 autoantibodies (6.25%). Anti-Dsg3 antibodies were detected in five patients (31.25%). Conclusions EPF from Peru shares epidemiological, clinical and immunological characteristics with other forms of EPF that have been described in South America.

Original languageEnglish (US)
Pages (from-to)594-600
Number of pages7
JournalClinical and Experimental Dermatology
Volume38
Issue number6
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Immunoglobulin G
Autoantibodies
Peru
Indirect Fluorescent Antibody Technique
Anti-Idiotypic Antibodies
Desmoglein 1
Enzyme-Linked Immunosorbent Assay
Pemphigus and fogo selvagem
Tunisia
Colombia
South America
Extracellular Space
Serum
Immunoprecipitation
Epidermis
Esophagus
Haplorhini
Brazil
Skin
Antibodies

ASJC Scopus subject areas

  • Dermatology

Cite this

Ortega Loayza, A., Ramos, W., Gutierrez, E. L., Jimenez, G., Rojas, I., & Galarza, C. (2013). Endemic pemphigus foliaceus in the Peruvian Amazon. Clinical and Experimental Dermatology, 38(6), 594-600. https://doi.org/10.1111/ced.12029

Endemic pemphigus foliaceus in the Peruvian Amazon. / Ortega Loayza, Alex; Ramos, W.; Gutierrez, E. L.; Jimenez, G.; Rojas, I.; Galarza, C.

In: Clinical and Experimental Dermatology, Vol. 38, No. 6, 01.08.2013, p. 594-600.

Research output: Contribution to journalArticle

Ortega Loayza, A, Ramos, W, Gutierrez, EL, Jimenez, G, Rojas, I & Galarza, C 2013, 'Endemic pemphigus foliaceus in the Peruvian Amazon', Clinical and Experimental Dermatology, vol. 38, no. 6, pp. 594-600. https://doi.org/10.1111/ced.12029
Ortega Loayza, Alex ; Ramos, W. ; Gutierrez, E. L. ; Jimenez, G. ; Rojas, I. ; Galarza, C. / Endemic pemphigus foliaceus in the Peruvian Amazon. In: Clinical and Experimental Dermatology. 2013 ; Vol. 38, No. 6. pp. 594-600.
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