End-stage lung disease: CT findings in 61 patients

Steven Primack, Thomas E. Hartman, David M. Hansell, Nestor L. Müller

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

PURPOSE: To determine whether the cause of end-stage lung disease could be determined on the basis of pattern and distribution of abnormalities at computed tomography (CT). MATERIALS AND METHODS: The CT scans from 61 consecutive patients with end-stage lung disease were independently assessed by two observers without knowledge of clinical or pathologic data. End-stage lung disease was defined by the presence of honeycombing, extensive cystic changes, or conglomerate fibrosis. The observers listed the three most likely diagnoses and recorded the degree of confidence in the first-choice diagnosis on a three-point scale. RESULTS: The observers made a correct first-choice diagnosis in an average of 87% of cases. A correct first-choice diagnosis was made most often in silicosis (100%), Langerhans cell histiocytosis (100%), asbestosis (90%), usual interstitial pneumonia (88%), extrinsic allergic alveolitis (87%), and sarcoidosis (83%). There was good agreement between the two observers on the first-choice diagnosis (kappa statistic, 0.89). CONCLUSION: The pattern and distribution of abnormalities in end-stage lung disease are determined by the underlying cause. In most cases, a specific diagnosis can be made on the basis of the CT findings.

Original languageEnglish (US)
Pages (from-to)681-686
Number of pages6
JournalRadiology
Volume189
Issue number3
StatePublished - Dec 1993
Externally publishedYes

Fingerprint

Lung Diseases
Tomography
Asbestosis
Extrinsic Allergic Alveolitis
Silicosis
Idiopathic Pulmonary Fibrosis
Langerhans Cell Histiocytosis
Sarcoidosis
Fibrosis

Keywords

  • Anaphylaxis and allergy, 60.635
  • Asbestosis, 60.773
  • Histiocytosis, 60.66
  • Lung, fibrosis, 60.792
  • Lung, interstitial disease, 60.792
  • Pneumoconiosis, 60.771
  • Sarcoidosis, 60.22

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Primack, S., Hartman, T. E., Hansell, D. M., & Müller, N. L. (1993). End-stage lung disease: CT findings in 61 patients. Radiology, 189(3), 681-686.

End-stage lung disease : CT findings in 61 patients. / Primack, Steven; Hartman, Thomas E.; Hansell, David M.; Müller, Nestor L.

In: Radiology, Vol. 189, No. 3, 12.1993, p. 681-686.

Research output: Contribution to journalArticle

Primack, S, Hartman, TE, Hansell, DM & Müller, NL 1993, 'End-stage lung disease: CT findings in 61 patients', Radiology, vol. 189, no. 3, pp. 681-686.
Primack S, Hartman TE, Hansell DM, Müller NL. End-stage lung disease: CT findings in 61 patients. Radiology. 1993 Dec;189(3):681-686.
Primack, Steven ; Hartman, Thomas E. ; Hansell, David M. ; Müller, Nestor L. / End-stage lung disease : CT findings in 61 patients. In: Radiology. 1993 ; Vol. 189, No. 3. pp. 681-686.
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