Encephalopathy associated with cryoprecipitable Australia antigen

Roger N. Rosenberg; Edward A. Neuwelt; Joel Kirkpatrick; Peter Kohler

doi:10.1002/ana.410010319

Encephalopathy associated with cryoprecipitable Australia antigen

Roger N. Rosenberg, Edward A. Neuwelt, Joel Kirkpatrick, Peter Kohler

Research output: Contribution to journal › Article › peer-review

Abstract

A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.

Original language	English (US)
Pages (from-to)	298-300
Number of pages	3
Journal	Annals of Neurology
Volume	1
Issue number	3
DOIs	https://doi.org/10.1002/ana.410010319
State	Published - Mar 1977
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1002/ana.410010319

Cite this

@article{6790a81265544cbd90db29d3443a467b,

title = "Encephalopathy associated with cryoprecipitable Australia antigen",

abstract = "A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.",

author = "Rosenberg, {Roger N.} and Neuwelt, {Edward A.} and Joel Kirkpatrick and Peter Kohler",

year = "1977",

month = mar,

doi = "10.1002/ana.410010319",

language = "English (US)",

volume = "1",

pages = "298--300",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "3",

}

TY - JOUR

T1 - Encephalopathy associated with cryoprecipitable Australia antigen

AU - Rosenberg, Roger N.

AU - Neuwelt, Edward A.

AU - Kirkpatrick, Joel

AU - Kohler, Peter

PY - 1977/3

Y1 - 1977/3

N2 - A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.

AB - A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.

UR - http://www.scopus.com/inward/record.url?scp=0017461107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017461107&partnerID=8YFLogxK

U2 - 10.1002/ana.410010319

DO - 10.1002/ana.410010319

M3 - Article

C2 - 889319

AN - SCOPUS:0017461107

SN - 0364-5134

VL - 1

SP - 298

EP - 300

JO - Annals of Neurology

JF - Annals of Neurology

IS - 3

ER -

Encephalopathy associated with cryoprecipitable Australia antigen

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this