A 19‐year‐old white woman with urticaria, arthralgias, and hepatitis B–associated antigen in her serum developed a progressive encephalopathy despite only mild hepatic dysfunction. The patient's serum at 4°C produced a cryoprecipitate containing the hepatitis B–associated antigen and its antibody. Serum complement levels were borderline low. At autopsy, gross and histological examination of the brain revealed only mild residual cerebral edema. Indirect immunofluorescent studies of the cerebral cortex and choroid plexus showed no evidence of immune complex deposition. The patient's progressive encephalopathy may have been related to the presence of cryoprecipitable hepatitis B antigen, a relationship not previously reported.
ASJC Scopus subject areas
- Clinical Neurology