Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid

Sanjay V. Malhotra; Hua Zhao

doi:10.1002/chir.20132

Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid

Sanjay V. Malhotra, Hua Zhao

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Chiral α-amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N-ethyl pyridinium trifluoroacetate, [EtPy]⁺[CF₃OO]^-. A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution.

Original language	English (US)
Pages (from-to)	S240-S242
Journal	Chirality
Volume	17
Issue number	SUPPL.
DOIs	https://doi.org/10.1002/chir.20132
State	Published - 2005
Externally published	Yes

Keywords

Amino acids
Enzymatic resolution
Ionic liquid
Lipases
N-ethyl pyridinium trifluoroacetate

ASJC Scopus subject areas

Analytical Chemistry
Catalysis
Pharmacology
Drug Discovery
Spectroscopy
Organic Chemistry

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10.1002/chir.20132

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title = "Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid",

abstract = "Chiral α-amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N-ethyl pyridinium trifluoroacetate, [EtPy]+[CF3OO]-. A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution.",

keywords = "Amino acids, Enzymatic resolution, Ionic liquid, Lipases, N-ethyl pyridinium trifluoroacetate",

author = "Malhotra, {Sanjay V.} and Hua Zhao",

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T1 - Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid

AU - Malhotra, Sanjay V.

AU - Zhao, Hua

PY - 2005

Y1 - 2005

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AB - Chiral α-amino acids have been obtained via enzymatic resolution in ionic liquid medium. The acetyl esters of a series of amino acids were separated by enzyme porcine pancreas lipase (PPL) in an aqueous solution of N-ethyl pyridinium trifluoroacetate, [EtPy]+[CF3OO]-. A comparative study with organic solvent acetonitrile shows that the ionic liquids provide a better medium for enzymatic resolution.

KW - Amino acids

KW - Enzymatic resolution

KW - Ionic liquid

KW - Lipases

KW - N-ethyl pyridinium trifluoroacetate

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U2 - 10.1002/chir.20132

DO - 10.1002/chir.20132

M3 - Article

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JO - Chirality

JF - Chirality

IS - SUPPL.

ER -

Enantioseparation of the esters of α-N-acetyl amino acids by lipase in ionic liquid

Abstract

Keywords

ASJC Scopus subject areas

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