Enantioselective biocatalytic reactions on (±)-aryl alkyl ketones with native and modified porcine pancreatic lipase

Mofazzal Husain, Vineet Kumar, Rajesh Kumar, Najam A. Shakil, Sunil K. Sharma, Ashok K. Prasad, Carl E. Olsen, Rajendra K. Gupta, Sanjay V. Malhotra, Erik Van Der Eycken, Anthony L. Depass, Kalle Levon, Virinder S. Parmar

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Porcine pancreatic lipase (PPL), pre-incubated with acetophenone in tetrahydrofuran, fails to recognize ortho-and para-acyloxy functions with respect to the nuclear carbonyl group in (±)-2,4-diacyloxyphenyl alkyl ketones and produces novel aryl alkyl ketones in moderate-to-highly optically active forms; this result supports the hypothesis on the mechanism of action of PPL in deacylation reactions on peracylated polyphenolics.

Original languageEnglish (US)
Pages (from-to)172-184
Number of pages13
JournalBiocatalysis and Biotransformation
Volume28
Issue number3
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Aryl akyl ketones
  • Enzymatic deacylation
  • Lipase
  • Schiff's base complex

ASJC Scopus subject areas

  • Biotechnology
  • Catalysis
  • Biochemistry

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