Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient

James B. Lerenz, Ronald Hamilton, Debby W. Tsuang, Aimee Schantz, Darcy Vavrek, Eric B. Larson, Walter A. Kukull, Oscar Lopez, Douglas Galasko, Eliezer Masliah, Jeffrey Kaye, Randall Woltjer, Christopher Clark, John Q. Trojanowski, Thomas J. Montine

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78 Scopus citations

Abstract

Lewy-related pathology (LRP) is a common pathologic finding at autopsy in dementia patients. Recently criteria for categorizing types of LRP in dementia patients were published, though these criteria have yet to be systematically applied to large dementia samples. We examined a large (n = 208) referral-based autopsy sample for LRP, and applied the published criteria for LRP categorization to these cases. We found almost half (49%) of LRP positive cases from this sample were not classifiable. However, modifying the published criteria by reducing the number of regions requiring examination, allowing more variability in LRP severity scores within specific brain regions, and adding an amygdala predominant category permitted classification of 97% of LRP positive cases from the referral-based sample. Application of the modified criteria to an unrelated community-based autopsy sample (n = 226) allowed classification of 96% of LRP positive cases. Modest modifications in the published criteria permit a significantly greater number of dementia cases with LRP to be classified. In addition, this modification allows for more limited sampling of brain regions for classification of LRP. We propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalBrain Pathology
Volume18
Issue number2
DOIs
StatePublished - Apr 1 2008

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Keywords

  • Dementia
  • Lewy bodies
  • α-synuclein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

Cite this

Lerenz, J. B., Hamilton, R., Tsuang, D. W., Schantz, A., Vavrek, D., Larson, E. B., Kukull, W. A., Lopez, O., Galasko, D., Masliah, E., Kaye, J., Woltjer, R., Clark, C., Trojanowski, J. Q., & Montine, T. J. (2008). Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient. Brain Pathology, 18(2), 220-224. https://doi.org/10.1111/j.1750-3639.2007.00117.x