Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis

Martin Glatz, Jay Hyun Jo, Elizabeth A. Kennedy, Eric C. Polley, Julia A. Segre, Eric Simpson, Heidi H. Kong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background Emollients are a mainstay of treatment in atopic dermatitis (AD), a disease distinguished by skin bacterial dysbiosis. However, changes in skin microbiota when emollients are used as a potential AD preventative measure in infants remain incompletely characterized. Results We compared skin barrier parameters, AD development, and bacterial 16S ribosomal RNA gene sequences of cheek, dorsal and volar forearm samples from 6-month-old infants with a family history of atopy randomized to receive emollients (n = 11) or no emollients (controls, n = 12). The emollient group had a lower skin pH than the control group. The number of bacterial taxa in the emollient group was higher than in the control group at all sites. The Streptococcus salivarius proportion was higher in the emollient versus control groups at all sites. S. salivarius proportion appeared higher in infants without AD compared to infants with AD. A decrease in S. salivarius abundance was further identified in a separate larger population of older children demonstrating an inverse correlation between AD severity at sampling sites and S. salivarius proportions. Conclusions The decreased skin pH and the increased proportion of S. salivarius after long-term emollient use in infants at risk for developing AD may contribute to the preventative effects of emollients in high-risk infants.

Original languageEnglish (US)
Article numbere0192443
JournalPLoS One
Volume13
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Emollients
atopic dermatitis
Streptococcus salivarius
Atopic Dermatitis
Skin
microorganisms
Bacterial Skin Diseases
Control Groups
atopy
Dysbiosis
16S Ribosomal RNA
Cheek
Microbiota
rRNA Genes
Forearm
ribosomal RNA
nucleotide sequences
sampling
Genes
Sampling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Glatz, M., Jo, J. H., Kennedy, E. A., Polley, E. C., Segre, J. A., Simpson, E., & Kong, H. H. (2018). Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. PLoS One, 13(2), [e0192443]. https://doi.org/10.1371/journal.pone.0192443

Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. / Glatz, Martin; Jo, Jay Hyun; Kennedy, Elizabeth A.; Polley, Eric C.; Segre, Julia A.; Simpson, Eric; Kong, Heidi H.

In: PLoS One, Vol. 13, No. 2, e0192443, 01.02.2018.

Research output: Contribution to journalArticle

Glatz, Martin ; Jo, Jay Hyun ; Kennedy, Elizabeth A. ; Polley, Eric C. ; Segre, Julia A. ; Simpson, Eric ; Kong, Heidi H. / Emollient use alters skin barrier and microbes in infants at risk for developing atopic dermatitis. In: PLoS One. 2018 ; Vol. 13, No. 2.
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