Emerging role of RAB GTPases in cancer and human disease

Kwai W. Cheng, John P. Lahad, Joe Gray, Gordon Mills

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Emerging evidence implicates alterations in the RAB small GTPases and their associated regulatory proteins and effectors in multiple human diseases including cancer. We have recently shown that RAB25, located at chromosome 1q22, is amplified at the DNA level and overexpressed at the RNA level in ovarian and breast cancer. These changes correlated with a worsened outcome in both diseases. In addition, enforced expression of RAB25 in both breast and ovarian cancer cells decreased apoptosis and increased proliferation and aggressiveness in vivo, potentially explaining the worsened prognosis. A better understanding of genetic alterations as well as the physiologic and pathophysiologic roles of RAB GTPases may open new opportunities for therapeutic intervention and better outcomes.

Original languageEnglish (US)
Pages (from-to)2516-2519
Number of pages4
JournalCancer Research
Volume65
Issue number7
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Fingerprint

GTP Phosphohydrolases
Ovarian Neoplasms
Breast Neoplasms
Monomeric GTP-Binding Proteins
Neoplasms
Chromosomes
RNA
Apoptosis
DNA
Proteins
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Emerging role of RAB GTPases in cancer and human disease. / Cheng, Kwai W.; Lahad, John P.; Gray, Joe; Mills, Gordon.

In: Cancer Research, Vol. 65, No. 7, 01.04.2005, p. 2516-2519.

Research output: Contribution to journalArticle

Cheng, Kwai W. ; Lahad, John P. ; Gray, Joe ; Mills, Gordon. / Emerging role of RAB GTPases in cancer and human disease. In: Cancer Research. 2005 ; Vol. 65, No. 7. pp. 2516-2519.
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