Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Carlos F. Aylwin; Carlos A. Toro; Elizabeth Shirtcliff; Alejandro Lomniczi

doi:10.1111/jora.12385

Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Carlos F. Aylwin, Carlos A. Toro, Elizabeth Shirtcliff, Alejandro Lomniczi

Oregon National Primate Research Center

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

Original language	English (US)
Pages (from-to)	54-79
Number of pages	26
Journal	Journal of Research on Adolescence
Volume	29
Issue number	1
DOIs	https://doi.org/10.1111/jora.12385
State	Published - Mar 2019

ASJC Scopus subject areas

Cultural Studies
Developmental and Educational Psychology
Social Sciences (miscellaneous)
Behavioral Neuroscience

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abstract = "The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.",

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AB - The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

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Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Abstract

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