Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence

Carlos F. Aylwin, Carlos A. Toro, Elizabeth Shirtcliff, Alejandro Lomniczi

    Research output: Contribution to journalReview article

    9 Citations (Scopus)

    Abstract

    The adolescent transition begins with the onset of puberty which, upstream in the brain, is initiated by the gonadotropin-releasing hormone (GnRH) pulse generator that activates the release of peripheral sex hormones. Substantial research in human and animal models has revealed a myriad of cellular networks and heritable genes that control the GnRH pulse generator allowing the individual to begin the process of reproductive competence and sexual maturation. Here, we review the latest knowledge in neuroendocrine pubertal research with emphasis on genetic and epigenetic mechanisms underlying the pubertal transition.

    Original languageEnglish (US)
    Pages (from-to)54-79
    Number of pages26
    JournalJournal of Research on Adolescence
    Volume29
    Issue number1
    DOIs
    StatePublished - Mar 1 2019

    Fingerprint

    Epigenomics
    Gonadotropin-Releasing Hormone
    adolescence
    Sexual Maturation
    puberty
    Gene Regulatory Networks
    Gonadal Steroid Hormones
    Puberty
    Research
    Mental Competency
    brain
    Animal Models
    animal
    adolescent
    Brain

    ASJC Scopus subject areas

    • Cultural Studies
    • Developmental and Educational Psychology
    • Social Sciences (miscellaneous)
    • Behavioral Neuroscience

    Cite this

    Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence. / Aylwin, Carlos F.; Toro, Carlos A.; Shirtcliff, Elizabeth; Lomniczi, Alejandro.

    In: Journal of Research on Adolescence, Vol. 29, No. 1, 01.03.2019, p. 54-79.

    Research output: Contribution to journalReview article

    Aylwin, Carlos F. ; Toro, Carlos A. ; Shirtcliff, Elizabeth ; Lomniczi, Alejandro. / Emerging Genetic and Epigenetic Mechanisms Underlying Pubertal Maturation in Adolescence. In: Journal of Research on Adolescence. 2019 ; Vol. 29, No. 1. pp. 54-79.
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