TY - JOUR
T1 - Emergence and global spread of a dengue serotype 3, subtype III virus
AU - Messer, William B.
AU - Gubler, Duane J.
AU - Harris, Eva
AU - Sivananthan, Kamalanayani
AU - De Silva, Aravinda M.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.
AB - Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.
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U2 - 10.3201/eid0907.030038
DO - 10.3201/eid0907.030038
M3 - Article
C2 - 12899133
AN - SCOPUS:0038386683
SN - 1080-6040
VL - 9
SP - 800
EP - 809
JO - Emerging infectious diseases
JF - Emerging infectious diseases
IS - 7
ER -