Emergence and global spread of a dengue serotype 3, subtype III virus

William Messer, Duane J. Gubler, Eva Harris, Kamalanayani Sivananthan, Aravinda M. De Silva

Research output: Contribution to journalArticle

281 Citations (Scopus)

Abstract

Over the past two decades, dengue virus serotype 3 (DENV-3) has caused unexpected epidemics of dengue hemorrhagic fever (DHF) in Sri Lanka, East Africa, and Latin America. We used a phylogenetic approach to evaluate the roles of virus evolution and transport in the emergence of these outbreaks. Isolates from these geographically distant epidemics are closely related and belong to DENV-3, subtype III, which originated in the Indian subcontinent. The emergence of DHF in Sri Lanka in 1989 correlated with the appearance there of a new DENV-3, subtype III variant. This variant likely spread from the Indian subcontinent into Africa in the 1980s and from Africa into Latin America in the mid-1990s. DENV-3, subtype III isolates from mild and severe disease outbreaks formed genetically distinct groups, which suggests a role for viral genetics in DHF.

Original languageEnglish (US)
Pages (from-to)800-809
Number of pages10
JournalEmerging Infectious Diseases
Volume9
Issue number7
StatePublished - Jul 1 2003
Externally publishedYes

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Dengue Virus
Dengue
Severe Dengue
Viruses
Sri Lanka
Latin America
Disease Outbreaks
Hemorrhagic Fever with Renal Syndrome
Eastern Africa
Serogroup

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Messer, W., Gubler, D. J., Harris, E., Sivananthan, K., & De Silva, A. M. (2003). Emergence and global spread of a dengue serotype 3, subtype III virus. Emerging Infectious Diseases, 9(7), 800-809.

Emergence and global spread of a dengue serotype 3, subtype III virus. / Messer, William; Gubler, Duane J.; Harris, Eva; Sivananthan, Kamalanayani; De Silva, Aravinda M.

In: Emerging Infectious Diseases, Vol. 9, No. 7, 01.07.2003, p. 800-809.

Research output: Contribution to journalArticle

Messer, W, Gubler, DJ, Harris, E, Sivananthan, K & De Silva, AM 2003, 'Emergence and global spread of a dengue serotype 3, subtype III virus', Emerging Infectious Diseases, vol. 9, no. 7, pp. 800-809.
Messer W, Gubler DJ, Harris E, Sivananthan K, De Silva AM. Emergence and global spread of a dengue serotype 3, subtype III virus. Emerging Infectious Diseases. 2003 Jul 1;9(7):800-809.
Messer, William ; Gubler, Duane J. ; Harris, Eva ; Sivananthan, Kamalanayani ; De Silva, Aravinda M. / Emergence and global spread of a dengue serotype 3, subtype III virus. In: Emerging Infectious Diseases. 2003 ; Vol. 9, No. 7. pp. 800-809.
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