Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death.

Darren J. Malinoski, Pantelis Hadjizacharia, Ali Salim, Hubert Kim, Matthew O. Dolich, Marianne Cinat, Cristobol Barrios, Michael E. Lekawa, David B. Hoyt

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Intraluminal pancreatic enzymes have been shown in animal models to be associated with multiple organ failure after hemorrhagic shock, independent of pancreatitis. The translocation of these enzymes into the circulation may serve as a marker of hemorrhagic shock-induced gut ischemia in critically injured trauma patients. We hypothesized that serum amylase and lipase would be significantly elevated in patients presenting in hemorrhagic shock and in those who develop organ failure. METHODS:: Review of a prospective database at a level-1 trauma center from 2000 to 2005. Two thousand seven hundred eleven critically injured trauma patients without pancreatic injuries were evaluated for shock (systolic pressure 2 times the upper limit of normal for amylase (30-130 U/L) and lipase (7-60 U/L) were defined as elevated. Univariate analyses were performed with the Pearson's chi, and binary logistic regression was used to determine significant risk factors for organ failure. Results with a p value

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalThe Journal of trauma
Volume67
Issue number3
StatePublished - Sep 2009
Externally publishedYes

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Hemorrhagic Shock
Amylases
Lipase
Wounds and Injuries
Enzymes
Serum
Multiple Organ Failure
Trauma Centers
Pancreatitis
Shock
Ischemia
Animal Models
Logistic Models
Databases
Blood Pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Malinoski, D. J., Hadjizacharia, P., Salim, A., Kim, H., Dolich, M. O., Cinat, M., ... Hoyt, D. B. (2009). Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. The Journal of trauma, 67(3), 445-449.

Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. / Malinoski, Darren J.; Hadjizacharia, Pantelis; Salim, Ali; Kim, Hubert; Dolich, Matthew O.; Cinat, Marianne; Barrios, Cristobol; Lekawa, Michael E.; Hoyt, David B.

In: The Journal of trauma, Vol. 67, No. 3, 09.2009, p. 445-449.

Research output: Contribution to journalArticle

Malinoski, DJ, Hadjizacharia, P, Salim, A, Kim, H, Dolich, MO, Cinat, M, Barrios, C, Lekawa, ME & Hoyt, DB 2009, 'Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death.', The Journal of trauma, vol. 67, no. 3, pp. 445-449.
Malinoski DJ, Hadjizacharia P, Salim A, Kim H, Dolich MO, Cinat M et al. Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. The Journal of trauma. 2009 Sep;67(3):445-449.
Malinoski, Darren J. ; Hadjizacharia, Pantelis ; Salim, Ali ; Kim, Hubert ; Dolich, Matthew O. ; Cinat, Marianne ; Barrios, Cristobol ; Lekawa, Michael E. ; Hoyt, David B. / Elevated serum pancreatic enzyme levels after hemorrhagic shock predict organ failure and death. In: The Journal of trauma. 2009 ; Vol. 67, No. 3. pp. 445-449.
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